资源描述：
《Duffy抗原趋化因子受体参与人乳腺癌的淋巴结转移.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、·56··.临床研究ufv抗原趋化因子受体参与人乳腺癌的淋巴结转移欧周罗王杰侯意枫罗建民沈镇宙邵志敏。【摘要」目的探讨ufy抗原趋化因子受体(ARC)与乳腺癌患者淋巴结转移的关系方法乳腺癌原发灶组织标本75例,按淋巴结转移情况分为阳性组和阴性组,通过免疫组化技术检测,。DARCDARC表达并探讨其与乳腺癌淋巴结转移的关系结果淋巴结转移阳性组中强表达18例(.6%,DARC.6%),<48)淋巴结转移阴性组中强表达31例(81两组间差异有统计学意义(尸0.01)。DARC强表达组与弱表达组的微血管密度(MVD)分别为(35.67土17.96)/HP和(53.38土20.2
2、9)/HP,差异有统计学意义(尸<0.01)。此外,远处转移的,9DARC弱表达13例患者中有例.,.。、(692%)4例DARC强表达(308%)DARC表达与MvD淋巴结转移状态及肿瘤远处转移呈负,。相关而与患者的存活时间呈正相关结论人原发乳腺癌组织中DARC表达降低和MvD增加可能。易化肿瘤向淋巴结等远隔部位的转移Du;;【主题词】fy抗原趋化因子受体乳腺肿瘤淋巴结转移DOregdLa七00ofDu价an柱genreCePtorchemo拓ne(DARC)15ated初htlymphnode翎forasodeo.七15u〔口anr一,,,n一,m15inhb翻始t
3、OUhZou俪N`瓜万口UiY一ngLnzinS月百N似OU加.n~zou,一minrertit,rta,n,,z阮hS月”0hZiB~eroaCncnsIuetaCnceOH胡ilF以坛nU诚sr勿sha昭haiZ伏刃32刀aChi一,.sPoia以hor:SOin一:imi舫heomoCerTnd咭AHhZ而Eam汉认ao@羚hoAbs。,ctoeveanalyzehteerliatonshipbeeenDutinereeptoremisI】bjictorwt母an罗forheokenDARC)andhtemetastasispotenitalinhumanbrea
4、steaneer.Me山创如Berasteaneeritsuesceonsm(it如ents,upeaeeongtoteoephnoestsexnesiey75PatigorddrihlallymdautweeramldimhoiOtChemalforPorteinlevelofDARC.Mieorvesseldensiyt(MVD)waseountedbyendhotelialeemunlsino,tianedusingti一CD34an.ngpostiveunostnnginnoenmuevesantibdoyResulstSt印iDARCimmiailymphd,
5、it助doPiitve脚upswasdeteetedin31eases(81.6%)and18eases(48.6%),erspeetively(P<0.01).MvDwas35.67士17.96)/HPand53.35士20.29)/HpinDARCstorng即sitiveanesssitiveeasos<((dl脚(p0.01.Inthasepatientswithlung,bone,hepatiedistantmetasis13eases),9eases(6.2%w)ast(9)erDARCless即siitve,4eases(30·8%)weerDARCsto
6、rngposlti,.hTeeoer]ationeo亦eientwas一0.412bewteenDARCexperssionandMVDandtheeoers卯ndingvaluewas一0.346betweenDARCexperssionandlymphnodestatllsand一0,333betweenDARCexpressionanddsttmetastasisinasteeer.ianbreanoanegativeenteProeessoneoonesis,porbyhasCndiusonDARCm叮playrolihfanig罗andablanassoeia
7、tioniwhtthelymPhnodestauts.sruantigenereerehekines;Berastneoplasms;mvhonode[ubjcetwods1DfyotPmoyLmetaSlasls十。eeLI一(eotaxin)及ECxC族成血管性趋化因子乳腺癌是一种血管高度依赖性实体肿瘤当乳LR、,,腺癌生长到lm耐时即需要瘤内血管生成否则肿的过度表达可促进肿瘤的生长侵袭和转移因而调,,。。瘤将处于休眠状态既不能生长也不会发生转移节这些趋化因子的水平至关重要`一、一、DuELRCXC已知CC族趋化因子CCLI(I309
