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1、ORIGINALARTICLEDetectionofprecancerousgastriclesionsandgastriccancerthroughexhaledbreathHaithamAmal,1MarcisLeja,2,3'4KonradsFunka,2,3,4RobertsSkapars,2,3ArmandsSivins,2,3GuntisAncans,2,3IntaLiepniece-Karele,2,3,5llzeKikuste,2,4levaLasina,2HossamHaick1Am
2、alHretat.Gut2015;0:1-8.doi:10.1136/gutjnl-2014-308536AmalHretat.Gut2015;0:1-8.doi:10.1136/gutjnl-2014-308536►Additionalmaterialispublishedonlineonly.Toviewpleasevisitthejournalonline(hTtp://dx.doi.org/10.1136/gutjnl-2014-308536).1DepartmentofChemicalEng
3、ineeringandRussellBerrieNanotechnologyInstitute,Technion—IsraelInstituteofTechnology,Haifa,IsraelfacultyofMedicine,UniversityofLatvia,Riga,Latvia^DepartmentofResearch,RigaEastUniversityHospital,Riga,Latvia^DigestiveDiseasesCentreGASTRO,Riga,LatviaAcadem
4、icHistologylaboratory,Riga,LatviaCorrespondencetoProfessorHossamHaick,DepartmentofChemicalEngineeringandRussellBerrieNanotechnologyInstitute,Technion—IsraelInstituteofTechnology,Haifa3200003,Israel;hhossam@technion.ac.ilHAandMLcontributedReceived29Septe
5、mber2014Revised25January2015Accepted7February2015Tocite:AmalH,LejaM,FunkaK,etal.GutPublishedOnlineFirst:[pleaseincludeDayMonthYear)doi:10.1136/gutjnl-2014-308536ABSTRACTObjectivesTimelydetectionofgastriccancer(GC)andtherelatedprecancerouslesionscouldpro
6、videatoolfordecreasingbothcancermortalityandincidence.Design968breathsampleswerecollectedfrom484patients(including99withGC)fortwodifferentanalyses.Thefirstsamplewasanalysedbygaschromatographylinkedtomassspectrometry(GCMS)whileapplyingttestwithmultipleco
7、rrections(pvalue<0.017);thesecondbycross-reactivenanoarrayscombinedwithpatternrecognition.Forthelatter,70%ofthesampleswererandomlyselectedandusedinthetrainingsetwhiletheremaining30%constitutedthevalidationsetTheoperativelinkongastricintestinalmetaplasia
8、(OLGIM)assessmentstagingsystemwasusedtostratifythepresence/absenceandrisklevelofprecancerouslesions.PatientswithOLGIMstageslll-IVwereconsideredtobeathighrisk.ResultsAccordingtotheGCMSresults,patientswithcanceraswellasthoseathighr
