资源描述：
《高血压英文PPT精品课件ThePharmacistsRoleinTreating》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、ThePharmacists’RoleinTreatingHypertensionThomasOwens,MDSaintFrancisUniversityCERMUSAObjectivesEnhanceyourunderstandingofhypertensiontoincludecardiovascularrisks,management,andgoalsforindividualpatientsReviewanddiscussthecurrentpharmacotherapystandardsofcareforhyperten
2、sionDescribethepharmacist’sroleincounselingpatientsonhypertensivemedicationsHypertension>140/90mmHgUnitedStates:65millionadultsRiskfactorsinclude:Stroke,myocardialinfarction,heartfailure,peripheralvasculardisease,aorticdissection,chronicrenalfailureHypertensionpriceta
3、g:$59.7billionWexler&Feldman,2005HypertensionTypicalonsetseconddecadeoflifePrimaryHypertensionidentifiablebehaviorsSecondaryHypertensionmorediscreteCecil,2004EthnicGroupsAfricanAmericans43%female&39%maleRatio1:3Increaseinsodiumsensitivity?Caucasians28%female29%maleMex
4、icanAmericansRatio1:4or1:5DASHDietCecil,2004DietarySodiumIntakeSaltHypothesis?StronggeneticunderpinningADA,2005MetabolicSyndromeRiskofHypertensionincreaseswithBMIObesityaccountsfor50%to60%ofnewcasesofhypertensionCecil,2004PotentialCausesofHypertensionExpandedplasmavol
5、umeplussympatheticoveractivityPeripheralvasoconstrictionRenalsaltretentionRenalwaterretentionSleepApneawww.sleepconsultants.com,2007Cecil,2004BloodPressureEquationBloodPressure=CardiacOutputxPeripheralVascularResistanceMostpharmacologicagentslowerSomepharmacologicagen
6、tslowerSomepharmacologicagentslowerbothCecil,2004GeneticsofHighBPSympatheticup-regulationleadstoacascadeofeventsPeripheralvascularresistanceGeneticfactors30%ofcases2xaslikelyifparentshavehypertensionDiscoveryedge.mayo.com,2007;ADA,2003Systolic&Diastolic??Whatismoreimp
7、ortant?DependsonageLivelongenoughalmostalldevelopsystolichypertension12080systolicdiastolicCecil,2004AgeDependantRiseinBP(Whelton&Rocella,1995)FraminghamStudy(age:50-79)(Khan,Wong,Larson,&Levy,1999)SystolicHypertensionDecreaseddistensibilityoflargearteriesMajorityofun
8、controlledhypertensionDuetofocusondiastolicBPCecil,2004RiskofcardiovascularmortalitybysystolicBP(NationalHighBloodPressureEd
