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1、Lab-on-a-ChipTechnologyanditsApplicationtoDrugAnalysisDissertationzurErlangungdesDoktorgradesderNaturwissenschaftenderFakultätfürChemieundPharmaziederUniversitätRegensburg,DeutschlandvorgelegtvonKamalM.A.TolbaausÄgyptenSeptember2007Lab-on-a-ChipTechnologyan
2、ditsApplicationtoDrugAnalysisDissertationzurErlangungdesDoktorgradesderNaturwissenschaftenderFakultätfürChemieundPharmaziederUniversitätRegensburg,DeutschlandvorgelegtvonKamalM.A.TolbaausÄgyptenSeptember2007Lab-on-a-ChipTechnologyanditsApplicationtoDrugAnal
3、ysisDoctoralDissertationbyKamalM.A.TolbaFacultyofChemistryandPharmacy,UniversityofRegensburg,GermanySeptember2007ThisstudywasperformedattheMax-PlanckinstituteofcarbonresearchinMülheimanderRuhrandtheinstituteofanalyticalchemistry,chemo-andbiosensorsoftheUniv
4、ersityofRegensburgbetweenOctober2004andJuly2007underthesupervisionofProf.Dr.DetlevBelder.Dateofdefense:12.09.2007Committeeofdefense(Prüfungsausschuss):Chairperson(Vorsitzender):Prof.Dr.GeorgSchmeerFirstexpert(Erstgutachter):Prof.Dr.DetlevBelderSecondexpert(
5、Zweitgutachter):Prof.Dr.JörgHeilmannThirdexpert(Drittprüfer):Prof.Dr.AchimGöpferichListofpublications1-Belder,D.,Kohler,F.,Ludwig,M.,Tolba,K.,Piehl,N.,Coatingofpowder-blastedchannelsforhigh-performancemicrochipelectrophoresis,Electrophoresis2006,27,3277–328
6、3.2-Tolba,K.,Belder,D.,Fastquantitativedeterminationofdiureticdrugsintabletsandhumanurinebymicrochipelectrophoresiswithnativefluorescencedetection,Electrophoresis2007,28,2934–2941.3-Tolba,K.,Belder,D.,Fastdeterminationofcentralnervoussystemstimulantdrugsint
7、abletsandhumanurinebymicrochipelectrophoresiswithfluorescencedetection,incourseofsubmission.iThisthesisisdedicatedto:myparents,mywifeandmydaughtersiiAcknowledgementsIwouldliketothankmysupervisorProfessorDetlevBelderforhisusefuladviceandguidanceinthiswork.Wh
8、enheassignedmetomyfirstmicrofluidicproject,Ididnotrealizethatthisresearchismulti-disciplinaryasitcontainsmanyareasofscienceincludingbiology,physics,materialscience,surfacechemistry.Itrequiresabroadbasi
