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1、ThenewenglandjournalofmedicineoriginalarticleARandomizedTrialofLaparoscopicversusOpenSurgeryforRectalCancerH.JaapBonjer,M.D.,Ph.D.,CharlotteL.Deijen,M.D.,GaborA.Abis,M.D.,MiguelA.Cuesta,M.D.,Ph.D.,MartijnH.G.M.vanderPas,M.D.,EllyS.M.deLange-deKlerk,M.D.,Ph.D.,A
2、ntonioM.Lacy,M.D.,Ph.D.,WillemA.Bemelman,M.D.,Ph.D.,JohnAndersson,M.D.,EvaAngenete,M.D.,Ph.D.,JacobRosenberg,M.D.,Ph.D.,AloisFuerst,M.D.,Ph.D.,andEvaHaglind,M.D.,Ph.D.,fortheCOLORIIStudyGroup*AbstractBackgroundFromVUUniversityMedicalCenter(H.J.B.,Laparoscopicre
3、sectionofcolorectalcanceriswidelyused.However,robustevi-C.L.D.,G.A.A.,M.A.C.,M.H.G.M.P.,dencetoconcludethatlaparoscopicsurgeryandopensurgeryhavesimilarout-E.S.M.L.-K.)andAmsterdamMedicalCenter(W.A.B.)—bothinAmsterdam;comesinrectalcancerislacking.Atrialwasdesign
4、edtocompare3-yearratesofHospitalClinicIProvincialdeBarcelona,cancerrecurrenceinthepelvicorperinealarea(locoregionalrecurrence)andsur-Barcelona(A.M.L.);theDepartmentofvivalafterlaparoscopicandopenresectionofrectalcancer.Surgery,InstituteofClinicalSciences,Sahlgr
5、enskaAcademy,UniversityofGo-thenburg,SahlgrenskaUniversityHospi-Methodstal–Östra,Gothenburg,Sweden(J.A.,Inthisinternationaltrialconductedin30hospitals,werandomlyassignedpatientsE.A.,E.H.);HerlevHospital,DepartmentofSurgery,UniversityofCopenhagen,withasolitaryad
6、enocarcinomaoftherectumwithin15cmoftheanalverge,notCopenhagen(J.R.);andCaritasKranken-invadingadjacenttissues,andwithoutdistantmetastasestoundergoeitherlaparo-hausSt.Josef,Regensburg,Germanyscopicoropensurgeryina2:1ratio.Theprimaryendpointwaslocoregionalrecur-(
7、A.F.).AddressreprintrequeststoDr.BonjeratVUUniversityMedicalCenter,rence3yearsaftertheindexsurgery.Secondaryendpointsincludeddisease-freeDepartmentofSurgery,DeBoelelaanandoverallsurvival.1117,1081HVAmsterdam,theNether-lands,oratj.bonjer@vumc.nl.Results*Acomplet
8、elistofmembersoftheAtotalof1044patientswereincluded(699inthelaparoscopic-surgerygroupandColorectalCancerLaparoscopicorOpen345intheopen-surgerygroup).At3years,thelocoregional
