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1、J.Comp.Path.2018,Vol.158,93e149ESVP,ESTPandECVPProceedings201799TESCHOVIRUSASTHECAUSATIVEAGENTOFCELLTROPISMOFMIDDLEEASTRESPIRATORYENCEPHALOMYELITISONTWOSWINEFARMSINTHESYNDROMECORONAVIRUSINEXPERIMENTALLYNETHERLANDSINFECTEDDROMEDARIESyzS.Vreman*,N.Caliskan,
2、K.Peperkamp,J.Kortekaas*andA.Lehmbecker*,A.-K.Uhde*,I.Spitzbarth*,P.Wohlsein*,xyyyyB.KolpaJ.vandenBrand,V.Raj,S.L.Smits,D.Schippers,*WageningenBioveterinaryResearch,Lelystad,yDepartmentofPathobiology,T.M.Bestebroery,N.Okbay,T.Kuikeny,A.Bensaidz,zxzzxxUtre
3、chtUniversity,GDAnimalHealth,DeventerandGelreDierenartsen,D.SolanesFoz,J.Segales,A.Volz,G.Sutter,{yGroenlo,TheNetherlandsA.D.M.E.Osterhaus,B.L.HaagmansandW.Baumgartner€*Introduction:Porcineteschovirus(PTV)belongstothegenusTe-*DepartmentofPathology,Univers
4、ityofVeterinaryMedicineHannover,yschovirusinthefamilyPicornaviridae.ThisviruscirculatesamongFoundation,DepartmentofViroscience,ErasmusMedicalCenter,Rotterdam,zxwildanddomesticatedpigpopulationswithoutcausinganyhealthNetherlands,CentredeRecercaenSanidatAni
5、mal,Barcelona,Spain,Germanproblems.However,apathogenicvariantPTV1(Teschendisease),CentreforInfectionResearch(DZIF),InstituteforInfectiousDiseasesand{orco-infectionwithimmunosuppressivevirusessuchasporcinerepro-Zoonoses,Ludwig-Maximilians-Universit€atM€unc
6、hen,MunichandGermanyductiveandrespiratorysyndromevirus(PRSSV)orporcinecircovi-ResearchCenterforEmergingInfectionsandZoonoses,UniversityofVeterinaryrus(PCV),couldresultinseriouseconomiclossesintheswineMedicineHannover,Foundation,Hannover,Germanyindustry.We
7、examinedweanlingpigswithneurologicalsignsonIntroduction:MiddleEastrespiratorysyndromecoronavirustwoswinefarmsintheNetherlandstoidentifytheunderlyingcause.(MERS-CoV)hascausedhundredsofhumandeathssince2012.MaterialsandMethods:Pathologicalexaminationwasperfo
8、rmedThedromedary(Camelusdromedarius)issuggestedtoplayanimpor-onpigsfrombothfarms(n55).Afterhistologicalevaluation,braintantroleintheepidemiologyofthisemerginginfectiousdiseaseandandspinalcordsampleswereusedforPCR,vi
