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1、BiologicalPsychology79(2008)70–79ContentslistsavailableatScienceDirectBiologicalPsychologyjournalhomepage:www.elsevier.com/locate/biopsychoQuantifyingtheheritabilityoftask-relatedbrainactivationandperformanceduringtheN-backworkingmemorytask:AtwinfMRIstudya,b,dbb,eabGabrie¨llaA.M.Bloklan
2、d,KatieL.McMahon,JanHoffman,GuZhu,MatthewMeredith,acb,1a,1,*NicholasG.Martin,PaulM.Thompson,GreigI.deZubicaray,MargaretJ.WrightaGeneticEpidemiologyLaboratory,QueenslandInstituteofMedicalResearch,Brisbane,AustraliabFunctionalMRILaboratory,CentreforMagneticResonance,UniversityofQueensland
3、,Brisbane,AustraliacLaboratoryofNeuroImaging,DepartmentofNeurology,UCLASchoolofMedicine,LosAngeles,CA,USAdDepartmentofBiologicalPsychology,FreeUniversity,Amsterdam,TheNetherlandseDepartmentofBiomedicalEngineering,HamburgUniversityofAppliedSciences,GermanyARTICLEINFOABSTRACTArticlehistor
4、y:Workingmemory-relatedbrainactivationhasbeenwidelystudied,andimpairedactivationpatternsReceived14January2008havebeenreportedforseveralpsychiatricdisorders.WeinvestigatedwhethervariationinN-backAccepted12March2008workingmemorybrainactivationisgeneticallyinfluencedin60pairsoftwins,(29mono
5、zygotic(MZ),31Availableonline16March2008dizygotic(DZ);meanage24.41.7S.D.).Task-relatedbrainresponse(BOLDpercentsignaldifferenceof2minus0-back)wasmeasuredinthreeregionsofinterest.AlthoughstatisticalpowerwaslowduetothesmallKeywords:samplesize,formiddlefrontalgyrus,angulargyrus,andsuprama
6、rginalgyrus,theMZcorrelationswere,inTwinstudygeneral,approximatelytwicethoseoftheDZpairs,withnon-significantheritabilityestimates(14–30%)intheHeritabilitylow-moderaterange.Taskperformancewasstronglyinfluencedbygenes(57–73%)andhighlycorrelatedfMRIwithcognitiveability(0.44–0.55).Thisstudy,w
7、hichwillbeexpandedoverthenext3years,providesthefirstWorkingmemorysupportthatindividualvariationinworkingmemory-relatedbrainactivationistosomeextentinfluencedbyDorsallateralprefrontalcortexMultivariategeneticmodellinggenes.Individualdifferencesß2008ElsevierB.V.Allrightsreserved.1.