The Diels-Alder Reaction in Total Synthesis

The Diels-Alder Reaction in Total Synthesis

ID:39814367

大小:1.51 MB

页数:31页

时间:2019-07-11

The Diels-Alder Reaction in Total Synthesis_第1页
The Diels-Alder Reaction in Total Synthesis_第2页
The Diels-Alder Reaction in Total Synthesis_第3页
The Diels-Alder Reaction in Total Synthesis_第4页
The Diels-Alder Reaction in Total Synthesis_第5页
资源描述:

《The Diels-Alder Reaction in Total Synthesis》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库

1、REVIEWSTheDiels±AlderReactioninTotalSynthesisK.C.Nicolaou,*ScottA.Snyder,TamsynMontagnon,andGeorgiosVassilikogiannakisTheDiels±Alderreactionhasbothfacilitatingcomplexmoleculecon-reviewinthecontextoftotalsynthesisenabledandshapedtheartandsciencestruction,theDiels±Aldercycl

2、oaddi-toillustrateitsoverallversatilityandoftotalsynthesisoverthelastfewtionhasaffordednumerousandun-underscoreitsvastpotentialwhichhasdecadestoanextentwhich,arguably,paralleledsolutionstoadiverserangeyettobefullyrealized.hasyettobeeclipsedbyanyotherofsyntheticpuzzlesprov

3、idedbynaturetransformationinthecurrentsyntheticintheformofnaturalproducts.InKeywords:biomimeticsynthesis¥repertoire.Withmyriadapplicationsofcelebrationofthe100thanniversaryofcycloaddition¥Diels±Alderthismagnificentpericyclicreaction,Alder×sbirth,selectedexamplesofthereact

4、ion¥moleculardiversity¥totaloftenasacrucialelementinelegantawesomepowerofthereactionhesynthesisandprogrammedcascadesequenceshelpedtodiscoverarediscussedinthis1.IntroductionAfternumerousnear-discoveriesofthe[42]cycloadditionreactionbyseveralluminariesinthefieldoforganicche

5、mistryduringtheearlypartofthe20thcentury,[1,2]thekeeninsightofProfessorOttoDiels[3]andhisstudent,KurtAlder,[4]inproperlyidentifyingtheproducts(4and6,Scheme1)arisingfromthereactionofcyclopentadiene(1)withquinone(2)denotesahistoriceventinthefieldofchemistryforwhichthesetwoi

6、ndividualswererewardedwithareactionthatwouldhenceforthbeartheirnames.[5]Withpropheticfore-sight,DielsandAlderclearlyanticipatedtheimportanceofthisdiscoveryintheirlandmark1928paper,particularlyasappliedtonaturalproductsynthesis,throughthefollowingremark:™Thusitappearstoust

7、hatthepossibilityofsynthesisofcomplexcompoundsrelatedtooridenticalwithnaturalproductssuchasterpenes,sesquiterpenes,perhapsevenalkaloids,hasbeenmovedtothenearprospect.∫However,inanintriguingmomentofscientificterritoriality,whichmightappearslightlyoff-colororevenamusingtoac

8、ontem-[*]Prof.Dr.K.C.Nicolaou,S.A.Snyder,Dr.T.Montagnon,Dr.G.VassilikogiannakisScheme1.Thediscov

当前文档最多预览五页,下载文档查看全文

此文档下载收益归作者所有

当前文档最多预览五页,下载文档查看全文
温馨提示:
1. 部分包含数学公式或PPT动画的文件,查看预览时可能会显示错乱或异常,文件下载后无此问题,请放心下载。
2. 本文档由用户上传,版权归属用户,天天文库负责整理代发布。如果您对本文档版权有争议请及时联系客服。
3. 下载前请仔细阅读文档内容,确认文档内容符合您的需求后进行下载,若出现内容与标题不符可向本站投诉处理。
4. 下载文档时可能由于网络波动等原因无法下载或下载错误,付费完成后未能成功下载的用户请联系客服处理。