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1、Page1of21IOVSPapersinPress.PublishedonMay20,2009asManuscriptiovs.09-3486IOVSTitle:ThePrevalenceofNystagmus:TheLeicestershireNystagmusSurveyAuthors:1112NaginiSarvananthan,MylvaganamSurendran,ErylORoberts,SunilaJain,3314SheryThomas,NitantShah,FrankAProudlock,John
2、RThompson,RebeccaJ1531McLean,ChristopherDegg,GeoffreyWoodruffandIreneGottlob1.DepartmentofOphthalmology,RobertKilpatrickClinicalSciencesBuilding,LeicesterRoyalInfirmary,Leicester,LE27LX.2.DepartmentofOphthalmology,RoyalPrestonHospital,SharoeGreenLaneNorth,Fulwo
3、od,Preston,Lancashire,PR29HT3.DepartmentofOphthalmology,LeicesterRoyalInfirmary,InfirmaryRoad,LeicesterLE15WW4.DepartmentofEpidemiologyandHealthSciences,AdrianBuilding,UniversityofLeicester,UniversityRoad,Leicester,LE17RH5.DepartmentofMedicalPhysics,Sandringham
4、Building,LeicesterRoyalInfirmary,InfirmaryRoad,LeicesterLE15WWCorrespondingauthor:ProfessorIreneGottlob,UniversityofLeicester,RobertKilpatrickClinicalSciencesBuilding,LeicesterRoyalInfirmary,POBox65,Leicester,LE27LX,UnitedKingdom1Copyright2009byTheAssociationfo
5、rResearchinVisionandOphthalmology,Inc.IOVSPage2of21Telephone:+44(0)1162586291Fax:+44(0)1162558810E-mail:ig15@le.ac.ukWordcountWordcount(abstract):245wordsWordcount(maintext):3589wordsGrantinformationThisstudywasfundedbytheNystagmusNetwork,UK,theUniversityHospit
6、alsofLeicesterandtheUlverscroftFoundation.2Page3of21IOVSAbstractPurpose:Nystagmus,whichcanbeinfantileoracquired,affectsallages.Theprevalenceofnystagmusinthegeneralpopulationisunknown.Newgeneticresearchandtherapeuticmodalitiesareemerging.Previousestimateshavebee
7、nbasedonwiderophthalmicepidemiologicalstudieswithinspecificoccupationaloragegroups.WecarriedoutthefirstepidemiologicalstudytospecificallyestablishtheprevalenceofnystagmusinLeicestershireandRutland,UnitedKingdom.Methods:Threeindependentdatasourcesidentifiedindiv
8、idualswithnystagmusfromthehospitalandcommunity.Thefirstwasahospital-basedquestionnaireandclinicalsurvey(n=238).Thevisuallyimpairedservices(n=414)andeducationservices(n=193)i
