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1、[FrontiersinBioscienceE4,2476-2489,June1,2012]Veryearly-initiatedphysicalrehabilitationprotectsagainstischemicbraininjury1111121,211PengyueZhang,QiZhang,HongjianPu,YiWu,YulongBai,PeterS.Vosler,JunChen,HongShi,YanqinGao,1YongshanHu1DepartmentofRehabilitationofH
2、uashanHospital,StateKeyLaboratoryofMedicalNeurobiology,DepartmentofSportsMedicineandRehabilitation,TheYongheBranchofHuashanHospital,andInstituteofBrainSciences,FudanUniversity,2Shanghai200032,China,DepartmentofNeurology,UniversityofPittsburghSchoolofMedicine,P
3、ittsburgh,PA15261,USATABLEOFCONTENTS1.Abstract2.Introduction3.Materialsandmethods3.1.Animalmodeloftransientfocalcerebralischemia3.2.Treadmilltraining3.3.Tissuesectionpreparation3.4.Measurementofinfarctvolume3.5.Immunofluorescencestainingandimageanalysis3.6.Tis
4、sueprocessingandtotalRNAextraction3.7.Reversetranscriptionandsemi-quantitativereal-timeRT-PCR3.8.Blood–brainbarrierpermeabilityevaluation3.9.Brainwatercontentdetermine3.10.Behavioraltrainingandevaluations3.11.Statisticalanalysis4.Results4.1.PhysiologicalVariab
5、les4.2.VEIPRreducedinfarctvolume4.3.VEIPRinhibitedtheactivationofastrocytesandmicrogliacells4.4.VEIPRsuppressedproinflammatorycytokineandcelladhesionmoleculemRNAexpressionaftertFCI4.5.VEIPRimprovesBBBintegrityanddecreasesbrainedemaaftertFCI4.6.VEIPRpromotesfun
6、ctionalrecovery4.6.1.Neurologicaldeficits4.6.2.Motorfunction4.6.3.Spatiallearningandmemory5.Discussion6.Acknowledgements7.References1.ABSTRACT2.INTRODUCTIONRecentclinicaldatasuggestthatveryearlyinitiatedStrokeisamajorcauseofmortalityandchronicphysicalrehabilit
7、ation(VEIPR)within24hoursafterstrokeneurologicaldisabilityworldwide(AmericanHeartmayreducemorbidity.However,thereislimitedevidencetoAssociation,2009(1)).MostsurvivorsfromstrokesuffersupportthebeneficialeffectsofVEIPRandtheunderlyingfrommotordisability,cognitiv
8、edysfunction,andproblemsmechanismsareyetunknown.ThepresentstudyinvestigatedinlearningandbehaviorthatreducetheirabilitytoperformtheeffectofVEIPRonbraindamage,inflammation,andactivit
