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1、湖南师范大学学报（医学版）2013，10（4）JHunanNormalUniv（MedSci）75药物干预对高龄患者早期正常眼压性青光眼的预后影响颜美荣，李正贤，周一鸣，彭晓，张景瑶，佘永川(湖南师范大学第二附属医院，解放军第163医院，湖南长沙410003)【摘要】目的：探讨药物干预对高龄老人早期正常眼压性青光眼(NTG)的预后影响。方法：对18例(36眼)早期NTG患者随机分为对照组8例(16眼),不予药物治疗，治疗组10例(20眼)，给予常规抗青光眼药物治疗。随访18月，记录患者视力、眼压、视野及眼底情况并进行分析。结果：随访18月，对照
2、组视力较用药前下降，视野旁中心暗点范围扩大，杯盘比值上升，眼压差异无统计学意义。治疗组视力较用药前提高，眼压明显下降，13眼视野旁中心暗点范围缩小或消失，杯盘比值无变化。结论：NTG可导致视功能进行性恶化，尽早药物干预可控制病情，改善预后。【关键词】正常眼压性青光眼；高龄患者；视功能；药物干预；预后【中图分类号】R775【文献标识码】A【文章编号】1673-016X(2013)04-0075-03Effectsofdruginterventiononprognosisearlynormaltensionglaucomaforagedpatien
3、tsYanMeirong,LiZhengxian,ZhouYiming，PengXian，ZhangJingyao,SheYongchuan(SecondAffiliatedHospitalofHunanNormalUniversity,163thHospitalofPLA,Changsha410003,China)[Abstract]ObjectiveToinvestgatetheeffectofdruginterventionontheprognosisofearlynormaltensionglaucoma(NTG)foragedpati
4、ents.MethodsEighteencases(36eyes)withearlyNTGwererandomlydividedintotreatmentgroup10cases(20eyes)andcontrolgroup8cases(16eyes).Notreatmentwasgiventothecontrolgroup.Thetreatmentgroupwasgivenconventionalanti-glaucomadrug.Thevisualacuity,intraocularpressure,fundsandvisualfieldw
5、ereobservedandanalyzed.Allcaseswerefollowedupfor18months.ResultsAfter18monthsfollow-up,incontrolgroup,thevisualacuitywassignificantlydecreased,intraocularpressurewasmain-tainedinnormalrangesandnostatisticallysignificant,theratioofcuptodiscwasincreased,andtherangesofparacentr
6、alscotomainthevisualfielddefectwereenlarged.Inthetreatmentgroup,thevisualacuitywasin-creased,intraocularpressurewassignificantlydecreased,theratioofcuptodischadnochange,andtherangesofparacentralscotomainthevisualfielddefectwerelessenedordisappearedin13cases.ConclusionThevisu
7、alfunctionofNTGwillleadtoprogressivedeteriorationwithoutmedicalintervention,andthediseasecanbecon-troledandtheprognosiscanbeimprovedifthedruginterventionisconductedassoonaspossibleinearlyNTG.[Keywords]normaltensionglaucoma;visualfunction;drugintervention;prognosis青光眼是全世界排名第二
8、的致盲眼病，且位列典型，易导致漏诊误诊，大多数病例在体检中发现。[1]不可逆致盲眼病第一位。正常眼压性青光眼(nor-近年来NTG的发病率呈老年化趋势
