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1、January2012AminonaphthoquinonesinHeterocyclization9a,bcbAshrafA.Aly,*EsamA.Ishak,MusaedA.Alsharari,daNayefS.Al-Muaikel,andTarekM.I.BedairaChemistryDepartment,FacultyofScience,El-MiniaUniversity,61519El-Minia,EgyptbChemistryDepartment,CollegeofScience,Al-JoufUnivers
2、ity,Al-Jouf,Sakaka,SaudiArabiacChemistryDepartment,FacultyofScience,El-AzharUniversity,Assiut,EgyptdChemistryDepartment,CollegeofPharmacy,Al-JoufUniversity,Al-Jouf,Sakaka,SaudiArabia*E-mail:ashrafaly63@yahoo.comReceivedMay7,2010DOI10.1002/jhet.639Publishedonline18O
3、ctober2011inWileyOnlineLibrary(wileyonlinelibrary.com).Becauseoftheinterestingbiologicalactivitiesofaminonaphthoquinones,inthisreviewwesurveytwoclassesofamino-1,4-naphthoquinones:2,3-diamino-1,4-naphthoquinoneand2-amino-1,4-naphtho-quinone.Thereviewincludessyntheti
4、cmethodologiesfortheseclassesinadditiontotheirheterocycli-zationprocesses.J.HeterocyclicChem.,49,9(2012).ContentsPage1.Introduction102.Discussion112.1.2,3-Diamino-1,4-naphthoquinone112.1.1.Synthesis112.1.2.Reactions112.1.2.1.Substitutionreaction112.1.2.2.Synthesiso
5、fimidazoles112.1.2.3.Synthesisofthia-orselena-diazolederivatives122.1.2.4.Synthesisoffusedpyridinederivatives122.1.2.4.1.SynthesisofDiscorhabdinC122.1.2.4.2.Synthesisof1-aza-anthraquinones132.1.2.5.Synthesisofquinoxalinediones132.1.2.6.Synthesisofdiazepinederivativ
6、es142.2.Chemistryof2-amino-1,4-naphthoquinone142.2.1.Synthesis152.2.2.Reactions152.2.2.1.Substitutionreactions152.2.2.2.Synthesisofpyrroles152.2.2.3.Synthesisofazepinesderivatives192.2.2.4.Synthesisofindolesderivatives192.2.2.5.Synthesisofquinolinederivatives192.2.
7、2.6.Synthesisof1,4-dihydropyridines192.2.2.7.Synthesisofoxazine,terahydrobenzo[g]chinazolineandpyridoacridinesderivatives19Referencesandnotes20VC2011HeteroCorporation10A.A.Aly,E.A.Ishak,M.A.Alsharari,N.S.Al-Muaikel,andT.M.I.BedairVol491.INTRODUCTIONNaphthoquinonesa
8、rewidelydistributedinplants,fungi,andsomeanimals.Theirbiologicalactivitieshavebeenstudiedincludingtheireffectsonprokaryoticandeukaryo-ticcells[1,
