[精品][经典]阻塞性睡眠呼吸暂停低通气综合征合并肺动脉高压者血浆肾上腺髓质素、.doc

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1、［经典］阻塞性睡眠呼吸暂停低通气综合征合并肺动脉高压者血浆肾上腺髓质素、内皮素-1水平及意义阻塞性睡眠呼吸暂停低通气综合征合并肺动脉高压者血浆肾上腺髓质素、内皮素T水平及意义【摘要】冃的测定阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并肺动脉高压(pH)患者血浆肾上腺髓质素(adrenomedullin,ADM)>内皮素-1(ET-1)水平，并探讨其临床意义。方法选2002年3月至2004年10月在郑州大学第一附属医院经多导睡眠仪监测诊断的58例OSAHS患者，分为单纯OSAHS组、OSAHS并pH组，选取30名健康体检者为止常对照组。检测各组血浆ADM、ET

2、-1水平、RVPEP/AT、AHI、minSa0₂及TSa0₂水平，并进行相关性分析。结果单纯OSAHS组及OSAHS并pH组血浆ADM、ET-1水平［ADM:(54.19±11・60)pg/ml,ET-1:(52.2±8.96)pg/ml；ADM:(79.82±15・33)pg/ml,ET-1:(79.3±11・25)pg/ml］均高于止常对照组［ADM:(44.73±8.52)pg/ml,ET-1:(37.4±9.85)pg/ml,P<0.01］；OSAHS并pH组又高于单纯OSAHS组(P〈0・01)。经nCPA

3、P治疗后OSAHS并pH患者血浆ADM、ET-1水平明显降低［ADM:(79.82±15・33)pg/ml,ET-1:(79.3±11・25)pg/ml；ADM:(63.48±10.76)pg/ml,ET-1:(62.4±8.23)pg/ml,P<0.01］,血浆ADM水平始终与ET-1、RVPEP/AT、AHI、TSa0₂呈正相关,与minSa0₂呈负相关。结论ADM、ET-1可能参与了OSAHS患者pH的发生发展过程。【关键词】睡眠呼吸暂停;阻塞性；肺动脉高压；肾上腺髓质素；内皮素TTheplasmalevelso

4、fadrenomedullinandendothelin-1inpatientswithobstructivesleepapnea-hypopneasyndromeincorporatingpulmonaryhypertensionandtheirsignificanceCHENRui-ying,SUNPei-zong,JINJian-jun.DepartmentofRespiratoryMedicine,theFirstAffiliatedHospitalofZhengzhouUniversity,Zhengzhou450052,China[Abstract】

5、ObjectiveTostudytheplasmalevelsofadrenomedullin(ADM)andendothelin-1(ET-1)inpatientswithobstructivesleepapnea-hypopneasyndrome(OSAHS)incorporatingpulmonaryhypertension(pH)andtheirsignificaneeinthedevelopmentofpH.MethodsFifty-eightpatientswithOSAHSweredividedintopureOSAHSgroupandOSAHSi

6、ncorporatingpHgroup・Thirtyhealthysubjectsservedasanormalcontrolgroup・TheplasmaADMandET-1levels,RVPEP/AT,AHI,minSa0₂andTSa0₂weremeasuredandthecorrelationanalysed・ResultsTheplasmaADMandET~1levelsinpureOSAHSgroup[ADM:(54.19±11・60)pg/ml,ET-1:(52.2±8.96)pg/ml]andOSAH

7、SincorporatingpHgroup[ADM:(79.82±15・33)pg/ml,ET-1:(79.3+11.25)pg/ml]werebothsignificantlyhigherthanthoseincontrols[ADM:(44.73±8・52)pg/ml,ET-1:(37.4+9.85)pg/ml](P<0.01)andtheplasmaADMandET-1levelsinOSAHSincorporatingpHgroupwerehigherthanthoseinpureOSAHSgroup(P<0.01).TheplasmaADMandET-

8、1levelsinpat