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1、AcceptedManuscriptStructure-guideddesignofpotentandpermeableinhibitorsofMERScoronavirus3CLproteasethatutilizeapiperidinemoietyasanoveldesignelementAnushkaC.GalasitiKankanamalage,YunjeongKim,VishnuC.Damalanka,AthriD.Rathnayake,AnthonyR.Fehr,NurjahanMehz
2、abeen,KevinP.Battaile,ScottLovell,GeraldH.Lushington,StanleyPerlman,Kyeong-OkChang,WilliamC.GroutasPII:S0223-5234(18)30239-3DOI:10.1016/j.ejmech.2018.03.004Reference:EJMECH10269Toappearin:EuropeanJournalofMedicinalChemistryReceivedDate:7October2017Revi
3、sedDate:28February2018AcceptedDate:1March2018Pleasecitethisarticleas:A.C.GalasitiKankanamalage,Y.Kim,V.C.Damalanka,A.D.Rathnayake,A.R.Fehr,N.Mehzabeen,K.P.Battaile,S.Lovell,G.H.Lushington,S.Perlman,K.-O.Chang,W.C.Groutas,Structure-guideddesignofpotenta
4、ndpermeableinhibitorsofMERScoronavirus3CLproteasethatutilizeapiperidinemoietyasanoveldesignelement,EuropeanJournalofMedicinalChemistry(2018),doi:10.1016/j.ejmech.2018.03.004.ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservi
5、cetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthe
6、content,andalllegaldisclaimersthatapplytothejournalpertain.ACCEPTEDMANUSCRIPTMANUSCRIPTACCEPTEDACCEPTEDMANUSCRIPTStructure-GuidedDesignofPotentandPermeableInhibitorsofMERSCoronavirus3CLProteasethatUtilizeaPiperidineMoietyasaNovelDesignElement+^AnushkaC
7、.GalasitiKankanamalage,^YunjeongKim,VishnuC.Damalanka,AthriD.#@&Rathnayake,^AnthonyR.Fehr,NurjahanMehzabeen,KevinP.Battaile,Scott@%#*+Lovell,GeraldH.Lushington,StanleyPerlman,Kyeong-OkChang,WilliamC.Groutas,*^^DepartmentofChemistry,WichitaStateUniversi
8、ty,Wichita,Kansas67260+DepartmentofDiagnosticMedicine&Pathobiology,CollegeofVeterinaryMedicine,KansasStateUniversity,Manhattan,Kansas66506@ProteinStructureLaboratory,TheUniversityofKansas,Lawrence,Kansas66047,USAMANUSCRIPT&IMCA-CAT,Haup
