[精品][经典]膀胱癌患者血清血管内皮生长因子水平测定的临床意义.doc

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1、［经典］膀胱癌患者血清血管内皮生长因子水平测定的临床意义膀胱癌患者血清血管内皮生长因子水平测定的临床意义【摘耍】目的探讨膀胱癌(BC)患者血清血管内皮生长因子(VEGF)水平与BC分期、分级的关系及手术前后变化的临床意义。方法采用酶联免疫吸附试验(ELTSA)对62例BC患者术前、术后1个月、术后出现复发(19例)或远处转移(2例)者、50例正常人血清屮VEGF水平进行检测。结果BC组的血清VEGF水平(269.2±58.3)ng/L明显高于正常对照组(125.5±22.3)ng/L(P<0.01

2、),并与肿瘤的分期、分级相关；其中浸润性癌T2-T3(275.7±41.2)ng/L组明显高于浅表性癌Tis-Tl(214.6±32・4)ng/L组(卩〈0・01),浸润性癌T4(338.8±43.7)ng/L组明显高于T2-T3组(P<0.01),G3级VEGF水平(332.9±45.6)ng/L显著高于G1级(231.2±38.5)ng/L和G2级(252.6±45・3)ng/L,G1级和G2级之间差异无统计学意义。与术前相比，术后血清VEGF水平(142.4±31・8)ng/L明显下降(P〈

3、0・01)，而术后复发及转移组血清VEGF水平(256.3±93.2)ng/L再次明显上升高于正常对照组(卩〈0・01)。结论VEGF表达与膀胱癌的临床分期及病理分级相关，血清VEGF水平可作为膀胱癌患者手术前后病情监测及判断复发的一个新瘤标。【关键词】血管内皮生长因子(VEGF)；膀胱癌；酶联免疫吸附试验；监测复发TheclinicalvalueofserumVEGFmeasurementinpatientswithbladdercancerSHANZhong-jie,YANGQing-xian

4、g,HANQian-he,etal.DepartmentofUrology,theFifthPeople^sHospitalofZheng^houCity,Zheng^hou450003,China[Abstract]ObjectiveTosearchfortherelationoftheserumVEGFtothestagingandgradingofbladdercancer,andtheclinicalvalueoftheVEGFchangespreandpostoperation.Meth

5、odsTherearetwogroups,namedbladdercancergroup(62cases)andcontralgroup(50cases)whichconsistedofnormalpeople・TheELISAmethodwastakentomeasureserumVEGF・Inbladdercancergroup,thereare41patientswithBC>19patientswithrecurrencepostoperationand2patientswithdista

6、ntmetastasis.Thetotal62casesweremeasuredforthelevelofserumVEGFatonemonthspre-andpostoperation:afterrecurrenceanddistantinetastasisrespectively.ResultsTheserumVEGFofBCgroup(269.2±58・3)ng/Lishigherstatisticallycomparedtonorrmalcontralgroup(125・5+22.3)ng

7、/L(P〈0・01),andrelatestothestagingandgradingoftumors.ThedifferencsisstatisticallysignificantbetweenT2-T3(275.7±41.2)ng/LandTis-Tl(214.6±32・4)ng/L(P<0.01),T4(338.8±43.7)ng/LandT2-T3(P<0.01).TheVEGFofG3(332・9+45・6)ng/LelivatedsignificantlycomparedtoG1and

8、G2.ThedifferenceofVEGFbetweenG1(231.2+38・5)ng/LandG2(252・6±45.3)ng/Lisnotsignificantstatistically.Comparedtopreoperation,theserumVEGF(142.4±31.8)ng/Ldecreasedsignificantlypostoperation.Whenthebladdercancerrecurreormetastateddistantlypostoperat