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1、保乳手术与改良根治术治疗早期乳腺癌近远期疗效对比［摘要］目的：探讨保乳手术和改良根治术治疗早期乳腺癌的近远期疗效。方法：冋顾性分析2002年12月〜2007年12月我科诊治70例I、II期乳腺癌患者的临床资料,根据手术方式分为保乳手术组(BCT组)和改良根治术组(MRM组)，比较两组患者术后疗效和生存质量的羌异。结果：BCT组患者术后皮下积液、患侧上肢水肿和皮瓣坏死发生率低于MRM组,其屮在皮下积液方曲比较，差异有统计学意义(P〈0.05)。BCT纽•无患者因相关疾病死亡(0),3年存活率为100.0%,术后局部复发4例(11.4%),远处转移3例(8.6%)；MRM组随访结束时1例患
2、者死亡(2.9%),3年存活率为97.1%,术后局部复发5例(14.3%),远处转移4例(11.4%)。BCT组和MRM组患者在死亡率、3年存活率、局部复发和远处转移方血差异无统计学意义(P〉0.05)。BCT组术后随访的美容效果优、良率和生存质量评分均显著高于MRM组，弟异有高度统计学意义(P<0.001)o结论：保乳手术治疗早期乳腺癌术示并发症少，患者生存质量高，近远期疗效显著高于改良根治术。［关键词］乳腺癌；保乳手术；改良根治术［中图分类号］R737.9［文献标识码］A［文章编号］1673-7210(2011)12(b)-041-02Comparisonofrecentandlo
3、ng-termeffectonbreast-conservingtherapyandmodifiedradicalmastectomyinthetreatmentoftheearly-stagebreastcancerYANGJun,GUANXiuwen,WEIBingdcngTheFirstDepartmentofSurgery,thePeoplezsHospitalofHuangpiDistrietinWuhanCity,HubeiProvince,Wuhan430300,China［Abstract］Objective:Toexploretherecentandlong-term
4、effectonbreast-conservingtherapyandmodifiedradicalmastectomyinthetreatmentoftheearly-stagebreastcancer.Methods:Thedataof70casesofpatientswithearly-stagebreastcancerofgradeI,IIfromDecember2002toDecember2007wereretrospectivelyanalyzedanddividedintoBCTgroupandMRMgroupaccordingtotheirsurgicalmethodT
5、hecurativeeffectsandqualityoflifewerecompared・Results:Theincidenceofsubcutaneousfluid,ipsilateralupperextremityedema,flapnecrosisinBCTgroupwaslowerthanthatofMRMgroup,therewasasignificantdiffereneeinthesubcutaneousfluid(P<0.05).Nopatientdiedduetoassociateddiseases(0),thesurvivalrateofthreeyearswa
6、s100.0%,localrecurreneeaftersurgerywas4cases(IL4%),distantmetastasiswas3cases(8.6%);1patientdiedduetoassociateddiseases(2・9%),thesurvivalrateofthreeyearswas97.1%,localrecurreneeaftersurgerywas5cases(14・3%),distantmetastasiswas4cases(11.4%).Therewasnosignificantdifferencebetweenthetwogroupsinsurv
7、ivalrate,mortalityrateandlocalrecurreneerate(P>0.05).PostoperativecosmeticandqualityoflifeinBCTgroupweresignificantlyhigherthanthoseinMRMgroup(P<0.001).Conclusion:TherecentandIong-termeffectofBCTforthepatientswithearly-stage
