嵌段聚合物修饰的金纳米粒子的制备及表征.pdf

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1、第26卷第8期化学研究与应用V01．26．No．82014年8月ChemicalResearchandApplicationAug．，2014文章编号：1004．1656(2014)08—1237-06嵌段聚合物修饰的金纳米粒子的制备及表征翟翠萍，陈霞，李东风，高青雨(河南大学化学化工学院，河南开封475004)摘要：通过RAFr合成聚(甲基丙烯酸缩水甘油酯)_b．聚(乙二醇甲基丙烯酸酯)嵌段共聚物(PGMA-b-PMAPEG)，再用半胱氨酸(Cys)使PGMA中的环氧基团开环，制备含有巯基的两亲水嵌段聚合物PM

2、APEG-b-P(GMA．Cys)。并以其作为修饰剂，通过原位还原法使HAuC1在NaBH的还原下制备金／聚合物纳米复合粒子(Au@PMAPEG—b．P(GMA．Cys)NPs)。经FI’．IR、uV—vis、TG、XRD、TEM和DIS表征，发现金纳米复合粒子呈均匀分散的球形，平均粒径约为10nm，在527nm处出现了金纳米粒子的表面等离子共振吸收峰，金约占总重量的49％。由于外层嵌段共聚物的修饰作用，金纳米复合粒子在室温下放置6个月未发生粒子间的聚集。关键词：嵌段聚合物；修饰剂；原位还原；金纳米粒子；制备中图

3、分类号：0632．52文献标志码：APreparationandcharacterizati0nofgoldnanoparticlesstabilizedbydiblockcopolymersZHAICui—ping，CHENXia，LIDong—feng，GAOQing—yu’(CollegeofChemistryandChemicalEngineering，HenanUniversity，Kaifeng，Henan，475004，China)Abstract：Thediblockcopolymerofpoly

4、(2，3-epoxypropylmethacrylateglycidylmethacrylate)-b-poly(poly(ethyleneglyco1)meth—ylethermethacrylate)(PGMA-b-PMAPEG)waspreparedbyreversibleaddition-fragmentationchaintransfer(RAFT)polymeriza—tion．Thenthiol—functionalizedpolymerPMAPEG—b·P(GMA—Cys)wassynthesiz

5、edbythereactionofcysteine(Cys)withtheepoxygroupsofPGMA．Furthermore，usingMAPEG—b—P(GMA—Cys)asamodifier，Au@PMAPEG—b-P(GMA．Cys)NPshasbeensynthe-sizedbyin·situreductionofHAuC14withsodiumborohydride(NaBH4)asareduetant．Thegoldnanocompositeparticleswerechar-acterize

6、dbyUV—visible(UV-vis)，fouriertransforminfraredspectroscopy(Fr—IR)，thermalgravimetrieanalysis(TGA)，X-Raydif-fraction(XRD)，transmissionelectronmicroscopy(TEM)anddynamiclightscattering(DIS)，foundthatthegoldnanocompositeparticleswereuniformlydispersedsphericaland

7、theaveragesizeWritsabout10rim．UV-visiblespectradisplayedthatthesurfaceplasmaresonanceabsorptionpeakappearedatabout527nmforgoldnanocompositeparticles．TheTGAcurvesindicatedthatthepercentageofgoldinthegoldnanocompositeparticlesis49％．Thegoldcompositeparticlesdidn

8、otoccuraggregationbetweenparti-clesatroomtemperatureoversixmonthsbecausethemodificationoftheouterblockcopolymelt'．Keywords：blockpolymer；modefier；in—situreduction；goldnanoparticles；prepare