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1、阿托伐他汀治疗对急性冠脉综合征患者血清sCD40、sCD40L和MMP-9的影响阿托伐他汀治疗对急性冠脉综合征患者血清sCD40、sCD40L和MMP-9的影响摘要：冃的探讨急性冠脉综合征患者血清血清sCD40.SCD40L和MMP-9的变化，以及阿托伐他汀治疗对其的影响，初步探讨阿托伐他汀对急性冠脉综合征的预防与治疗机制。方法将120例急性冠脉综合征患者随机分为A组(n=60)和B组(n二60),A组常规治疗，B组在常规治疗基础上加服阿托伐他汀，在治疗前后分别测定每组患者血清sCD40、sCD40L和MMP-9水平。结杲急性冠脉综合征血清sCD40、SCD40L和9水平较对照组显著升高(
2、P〈0・05)；B组治疗后较治疗前及A组治疗后血清sCD40、SCD40L和MMP-9显著降低(P〈0・05),A组治疗前后血清sCD40、SCD40L和MMP-9差异无统计学意义(P>0.05)o结论血清sCD40、SCD40L和MMP-9可能与急性冠脉综合征发牛:发展有关，阿托伐他汀能显著降低急性冠脉综合征患者SCD40、SCD40L和MMP-9水平，治疗急性冠脉综合征的机制可能与调节血清sCD40、SCD40L和MMP-9水平有关。关键词：阿托伐他汀；急性冠脉综合征；sCD40L；sCD40L；MMP-9EffectofatorvastatinonthelevelsofsCD40L,
3、sCD40LandMMP-9inpatientswithacutecoronarysyndromeCHENFang(Departmentofcardiology,YiyangCentralHospital,Yiyang413000,Hunan,China)Abstract：ObjectiveToexplorethechangeofatorvastatinonacutecoronarysyndromepatientsandtheimpactsontheexpressionsofsCD40L,sCD40LandMMP-9,tostudythemechanismforitspreventiona
4、ndtreatmentofacutecoronarysyndrome・MethodsTheclinicalobservationofusingrandomizedcontroledmethod,120casesofacutecoronarysyndromepatientsweredividedintoAandBgroup・ThegroupAweretreatedonlywithconventionaltherapy,ThegroupBwasgivenatorvastatinbesidesconventionaltherapy.AndtheconcentrationsofsCD40L,sCD
5、40LandMMP-9inserumweredetectedbeforeandaftertherapy.ResultsThelevelofserumsCD40L、sCD40LandMMP-9inACSpatientsweresignificantincreaseastocontrolgroup(allP<0.05),andTheserumlevelofsCD40L,sCD40LandMMP-9onBgroupaftertreatmentwerelowerthanthosebeforetreatmentandAgroupaftertreatment(P<0.05),whiletheserum
6、levelofsCD40L,sCD40LandMMP-9onAgroupaftertreatmentwerenosignificantlydifferentwiththosebeforetreatment(P>0.05)・ConclusionTheremaybearelevantbetweenserumsCD40L,sCD40L,MMP-9andtheincideneeofacutecoronarysyndrome,atorvastatincansignificantlyreducethelevelsofsCD40L,sCD40L,MMP-9inacutecoronarysyndromep
7、atients,themechanismofatorvastatintreatacutecoronarysyndromemayberelatedtoregulatingtheserumlevelofsCD40L,sCD40LandMMP-9.Keywords：Atorvastatin；Acutecoronarysyndrome；sCD40L；sCD40L；MMP-9急性冠脉综合征(Acutecoronarysyndrom
