仔猪肠道疾病.ppt

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1、EntericDiseasesofYoungPigs仔猪肠道疾病Diarrhearemainsoneoftheleadingcausesofneonatalmortalityinswine下痢一直是新生仔猪死亡的主要原因DefinitionofDiarrhea下痢的定义Excesswaterinfecesrelativetodrymatter.粪中含水量过大Normally,muchofthefluidisabsorbedinthesmallintestinebeforeitexitstheileu

2、m通常，大部分水都在进入回肠之间就在小肠中被吸收了Colonservestoconservewaterandelectrolytes结肠只起吸收水和电解质的作用MechanismsofDiarrhea下痢的机理SecretoryDiarrhea分泌性下痢Resultoftheeffectofenterotoxinssecretedbybacteriaandsomeviruses细菌和其它病毒分泌的肠毒素造成的结果Alterationinsecretionofelectrolytes,water,an

3、dbicarbonate:gradientpullswaterintolumen电解质、水和碳酸氢钠的分泌发生改变：使水进入肠腔Absorptioncontinues:ChyleinlymphaticsMechanismsofDiarrhea下痢的机理MalabsorptiveDiarrhea吸收不良性下痢Reductioninsurfaceareaofintestine肠粘膜表面积减少Lossofabsorptivecapacity吸收能力减弱Villousatrophy绒毛萎缩Chyleabse

4、ntinlymphatics淋巴乳糜缺乏Undigestedingestaferments未消化的食糜发酵MechanismsofDiarrhea下痢的机理EffusiveDiarrhea渗漏性下痢Resultofseveredamagetomucosa粘膜严重受损的结果Necrotoxinsproducedbybacteria细菌产生的坏死毒素Leakageofserumproteinsandwaterduetovasculardamage血管受损导致血清蛋白质和水漏出Lossofabsorpti

5、vecapacity吸收能力减弱ArrivingataDiagnosis诊断History病史Ageofonset发病年龄Vaccinationhistory免疫接种历史Suddendeathvs.protracteddiarrhea猝死和长期下痢ArrivingataDiagnosis诊断Selectionofspecimens病料采集Diarrheaof24hrsorless下痢开始后24小时以内Untreated未经治疗Avoidpigswhich“diedduringthenight”不要从

6、夜间死亡的猪采集病料SelectingSegmentsofIntestine肠段的选择Histopathology组织病理学Sectionsrepresentativeofallareasofintestines要选择能代表肠道所有区域的部分Bettertohavemanysmallpiecesthanonelargepiece最好要采集多个较短肠段，而不要只采集一个很长的肠段Segments~1cmlong,openedlengthwise根据纵向尺寸的不同，采集1厘米左右的肠段Freshsamp

7、les样本要新鲜7–10cmsegmentsofileum,jejunum7～10厘米回肠和空肠的肠段Segmentofspiralcolon结肠螺旋襻的肠段SelectingSegmentsofIntestine肠段的选择Causesofpigdiarrheas仔猪肠炎原因NursingWeaning断奶前断奶后E.coli大肠杆菌11%49%Rotavirus轮状病毒14%12%C.perfringens19%0%产气荚膜梭状芽孢杆菌TGE传染性胃肠炎8%7%Coccidiosis球虫病20%1

8、5%Source-IowaStateDiagnosticLab2000-2002Colibacillosis-E.coli大肠杆菌病●分泌过度性下痢Hypersecretiondiarrhea●12小时至3～4天龄或更大的猪下痢Diarrheafrom12hoursto3-4days●可能极度水样化Maybeextremelywatery●随后发病的各窝猪更严重Increasesseverityinsucceedinglitters●头胎仔猪可能更严重Giltlitt