Inherited retinal degeneration basic FGF induces phagocyticcompetence in cultured RPE cells from RCS rats 遗传性视网膜变性:碱性成纤维细胞生长因子诱导吞噬作用 RCS大鼠培养RPE细胞地能力.pdf

Inherited retinal degeneration basic FGF induces phagocyticcompetence in cultured RPE cells from RCS rats 遗传性视网膜变性:碱性成纤维细胞生长因子诱导吞噬作用 RCS大鼠培养RPE细胞地能力.pdf

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时间:2020-03-27

Inherited retinal degeneration basic FGF induces phagocyticcompetence in cultured RPE cells from RCS rats 遗传性视网膜变性:碱性成纤维细胞生长因子诱导吞噬作用 RCS大鼠培养RPE细胞地能力.pdf_第1页
Inherited retinal degeneration basic FGF induces phagocyticcompetence in cultured RPE cells from RCS rats 遗传性视网膜变性:碱性成纤维细胞生长因子诱导吞噬作用 RCS大鼠培养RPE细胞地能力.pdf_第2页
Inherited retinal degeneration basic FGF induces phagocyticcompetence in cultured RPE cells from RCS rats 遗传性视网膜变性:碱性成纤维细胞生长因子诱导吞噬作用 RCS大鼠培养RPE细胞地能力.pdf_第3页
Inherited retinal degeneration basic FGF induces phagocyticcompetence in cultured RPE cells from RCS rats 遗传性视网膜变性:碱性成纤维细胞生长因子诱导吞噬作用 RCS大鼠培养RPE细胞地能力.pdf_第4页
Inherited retinal degeneration basic FGF induces phagocyticcompetence in cultured RPE cells from RCS rats 遗传性视网膜变性:碱性成纤维细胞生长因子诱导吞噬作用 RCS大鼠培养RPE细胞地能力.pdf_第5页
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1、FEBS18714FEBSLetters412(1997)21-29Inheritedretinaldegeneration:basicFGFinducesphagocyticcompetenceinculturedRPEcellsfromRCSratsM.J.McLaren1>a'*,G.Inanab'^DepartmentofPhysiologyandBiophysics,UniversityofMiamiSchoolofMedicine,Miami,FL33136,USAhLaboratoryofMolecularGenetics,BascomPalmerEyeInstitute,

2、UniversityofMiamiSchoolofMedicine,Miami,FL33136,USAReceived17March1997;revisedversionreceived28April1997scavengerreceptorCD36[14],aswellasotherunknownpro-AbstractInRCSrats,theretinalpigmentepithelium(RPE)isteinsofRPEplasmamembranes[15,16],havebeenproposeddefectiveinphagocytosisofphotoreceptormemb

3、ranes.WehavepreviouslyshownreducedexpressionofbasicfibroblastgrowthascandidatesfortheROSreceptor.factor(bFGF)intheRPEof7-10-day-oldRCSrats.ThisstudyBasicFGF(FGF-2)isawidelydistributedheparin-bindingusingprimaryRPEculturesfromratsofthisagedemonstratesgrowthfactorwitharemarkablydiverserangeofaction

4、scrit-thatthephagocyticdefectinthemutantRPEcanbeovercomeicalinnormaldevelopment,reproduction,angiogenesisandbytreatmentwithbFGF,byamechanisminvolvinggeneresponsesofthenervoussystemtoinjury[17-23].AlthoughtranscriptionandthatnormalRPEphagocytosis,alsorequiringintraocularinjectionofseveraldifferent

5、neurotrophicfactorstranscription,isblockedbyabFGFneutralizingantibody.TheincludingbFGFhasbeenshowntoprotectnormalratphoto-combineddatapointtoaroleforbFGFinthenormalmechanismreceptorsfrominsultssuchaslightdamage[24]andphysicalofRPEphagocytosisandtheRCSdefect.trauma[25],onlybFGFhasbeenshowntodelayt

6、hedemise©1997FederationofEuropeanBiochemicalSocieties.ofthephotoreceptorsintheRCSmodelofinheritedretinaldegeneration[26].WehaverecentlyshownthatbFGFmRNAKeywords:Basicfibroblastgrowthfactor;RPEcell;andproteinexpressionaremarkedlydown-regulatedinthePhagocytosis;RCSrat;InheritedretinaldegenerationRP

7、EofRCSratsduringthedevelopmentalperiod(P7-P12)whenexpressionofthephagocyticdefectfirstoccursinvivo[27].SincetheprimarygeneticdefectresidesintheRPEin1.Introductionthismodel[7],thepresentinvestigationtestedwhetherexoge-n

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