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1、Downloadedfromorbit.dtu.dkon:21,2018KinMutRF:arandomforestclassifierofsequencevariantsinthehumanproteinkinasesuperfamilyPons,Tirso;Vazquez,Miguel;Matey-Hernandez,MaríaLuisa;Brunak,Søren;Valencia,Alfonso;Gonzalez-Izarzugaza,JoseMariaPublishedin:BMCGenomicsLinktoarticle,DOI:10.
2、1186/s12864-016-2723-1Publicationdate:2016DocumentVersionPublisher'sPDF,alsoknownasVersionofrecordLinkbacktoDTUOrbitCitation(APA):Pons,T.,Vazquez,M.,Matey-Hernandez,M.L.,Brunak,S.,Valencia,A.,&Gonzalez-Izarzugaza,J.M.(2016).KinMutRF:arandomforestclassifierofsequencevariantsin
3、thehumanproteinkinasesuperfamily.BMCGenomics,17(Suppl.2),[396].DOI:10.1186/s12864-016-2723-1GeneralrightsCopyrightandmoralrightsforthepublicationsmadeaccessibleinthepublicportalareretainedbytheauthorsand/orothercopyrightownersanditisaconditionofaccessingpublicationsthatusersr
4、ecogniseandabidebythelegalrequirementsassociatedwiththeserights.•Usersmaydownloadandprintonecopyofanypublicationfromthepublicportalforthepurposeofprivatestudyorresearch.•Youmaynotfurtherdistributethematerialoruseitforanyprofit-makingactivityorcommercialgain•Youmayfreelydistri
5、butetheURLidentifyingthepublicationinthepublicportalIfyoubelievethatthisdocumentbreachescopyrightpleasecontactusprovidingdetails,andwewillremoveaccesstotheworkimmediatelyandinvestigateyourclaim.Ponsetal.BMCGenomics2016,17(Suppl2):396DOI10.1186/s12864-016-2723-1METHODOLOGYARTI
6、CLEOpenAccessKinMutRF:arandomforestclassifierofsequencevariantsinthehumanproteinkinasesuperfamily1†1†22,31TirsoPons,MiguelVazquez,MaríaLuisaMatey-Hernandez,SørenBrunak,AlfonsoValencia2*andJoseMGIzarzugazaFromVarI-SIGatISMB2015Dublin,Ireland.07November2015AbstractBackground:Th
7、eassociationbetweenaberrantsignalprocessingbyproteinkinasesandhumandiseasessuchascancerwasestablishedlongtimeago.However,understandingthelinkbetweensequencevariantsintheproteinkinasesuperfamilyandthemechanisticcomplextraitsatthemolecularlevelremainschallenging:cellstoleratemo
8、stgenomicalterationsandonlyaminorfractiondisruptmolecularfunctionsuf
