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1、TherapeuticpotentialofGastrodiaelataBlumeforthetreatmentofAlzheimer?sdiseaseGuang・BiaoHuangTongZhaol,SushmaShresthaMuna1,Hong-MeiJinJong・llPark1,Kyu-SikJo2,Bo-HeeLee2,Soo・WanChae3,Sun・YoungKim3,Soo-HyunPark3,Eun-OckPark3,Eun-KyungChoi3,Young-ChuiChung1,41DepartmentofPsychiatry,ChonbukNationalUniver
2、sityMedicalSchool,Jeonju561・756,RepublicofKorea2MujuChunmaNativeLocalIndustrialCenter,Muju568-844,RepublicofKorea3ClinicalTrialCenterforFunctionalFoods,ChonbukNationalUniversityHospital,Jeonju561・756,RepublicofKorea4DepartmentofPharmacology,ChonbukNationalUniversityMedicalSchool,Jeonju561・756,Republ
3、icofKorea5ResearchInstituteofClinicalMedicineofChonbukNationalUniversity-BiomedicalResearchInstituteofChonbukNationalUniversityHospital,Jeonju561-756,RepublicofKorea摘要研究证实，屮草药天麻可减少淀粉样beta蛋白诱导的细胞凋亡。为研究天麻对阿尔茨海默病的可能治疗作用，我们将淀粉样beta蛋A25-35注射于大鼠双侧海马，建立阿尔茨海默病大鼠模型，然后连续52d每口灌胃500或1000mg/kg天麻。治疗结束后，Morris水迷宫试
4、验评佔显示阿尔茨海默病人鼠空间记忆功能明显改善，刚果红染色显示阿尔茨海默病大鼠海马淀粉样沉积明显减少，Westernblotting和Ellman法检测显示阿尔茨海默病大鼠额前皮质、内侧隔核和海马腹碱乙酰基转移酶表达上升，乙酰胆.碱酯酶活性明显下降。说明长期应用天麻治疗阿尔茨海默病是很有改善症状潜力的方法。关键词：神经再化;中医药;人麻;阿尔茨衙默桶;老年痴呆;水迷宫试验;胆碱乙酰丛转移曲:乙醸胆碱施场;堪金资助文章；Acceptancedate:2012-11-06Citethisarticle:Guang-BiaoHuang,TongZhao.SushmaShresthaMuna,Hong
5、・MeiJin,Jong・llPark,Kyu・SikJo,Bo・HeeLee,Soo・WanChae,Sun・YoungKim,Soo・HyunPark,Eun-OckPark,Eun・KyungChoi,Young-Chul・TherapeuticpotentialofGastrodiaelataBlumeforthetreatmentofAlzheimer'sdiseasefJ]・NeuralRegenerationResearch,2013,8(12):
