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《室壁局部功能测定对靶剂量培哚普利联合美托洛尔治疗急性心肌梗死合并心功能不全疗效评价.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、室壁局部功能测泄对靶剂量培味普利联合美托洛尔治疗急性心肌梗死合并心功能不全疗效评价［摘要］目的：利用实时三维超声心动图(RT-3DE)测量左室16个节段的局部容积-时间1山线(LVRV-TC)及左室节段射血分数-时间
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3、线(REF-TC)评价靶剂量培味普利联合美托洛尔治疗急性心肌梗死(AMT)合并左心功能不全患者的临床疗效。方法：46例AMI合并左心功能不全患者随机分为对照组和治疗组，随访半年，观察两组治疗前示RT-3DE左室射血分数(RLVEF),LVRV-TC指标包括局部舒张末期容积(R
4、EDV)、收缩末期容积(RESV)以及REF-TC值的变化。其屮，对照纟ft给予AMI常规治疗，包括阿司匹林和(或)氯II比格雷、他汀类药、硝酸酯类药，常规剂量的美托洛尔(25mg,每2次)、培味普利(2〜4mg,每LI1次)及111!美他嗪等；治疗组在对照组的基础上使用靶剂量的培味普利8mg/d.美托洛尔200mg/d或达最大I耐受剂量。结果：两组患者治疗前一般资料比较，养异无统计学意义(P>0.05)；两组治疗后RLVEF、REF与治疗前比较,差异有统计学意义(P<0.05,P<0.01)；
5、对照组和治疗组治疗示REF纟R间比较差异有统计学意义(P<0.05)；治疗过程屮两纟fl不良反应差异无统计学意义(P<0.05)o结论：靶剂量的培味普利联合美托洛尔治疗对AMI合并左心功能不全患者受损节段心肌重构效果较常规剂量更好。［关键词］超声心动描记术；实时三维；心肌梗死；心室功能；靶剂量［中图分类号］R541；R445.1［文献标识码］B［文章编号］1673-7210(2011)07(c)-099-04Evaluationofcurativeeffectofpatientswithacut
6、emyocardialinfarctionwithleftheartinsufficiencywithPerindoprilcombinedMetoprololbydeterminationleftventricularregionalfunct.ionNIHua,LIUChengying,SHAJiangming,SHAORong,SHENYi,GAOChunheng,WANGDongshengJiangyinAffiliatedHospitalofSoutheastUniversity,Ji
7、angsuProvince,Jiangyin214400,China［Abstract］Objective:ToevaluatethecurativeeffectofleftventricularregionalfunctionofthepatientswithacutemyocardialinfarctionwithleftheartinsufficiencywithPerindoprilcombinedMetoprololbyreal-timethree-climensionalechoca
8、rdiography(RT-3DE).Methods:46AMTpatientswithleftheartinsufficiencyweredividedintocontrolgroupandtreatmentgrouprandomlyandfollowedupforsixmonths,three-dimensionalimagedatawereacquiredanalyzedoffline.Regionalvolumecurvesandregionalejectionfractioncurve
9、swerederived.Regionaldiastolicvolumes,regionalsystolicvolumesandregionalejectionfractionswerecomparedrespective!ybetweentwogroups.ControlgroupreceivedconventionalAMTtherapy,includingAspirinand(or)Clopidogrel,Statins,Nitrates,conventionaldosesofMetopr
10、olol(25mg,2timesaday),Perindopril(2-4mg,1timeaday)anc)Triinetazidine,etal;thetreatmentgroupusedofthetargetdoseofPerindopril8mg/d,Metoprolol200mg/doruptoMaximumtolerateclcloseonthebasisofcontrolgroup・Results:Thegeneralinformationhadnosignificantdiffer
