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1、第35卷第1期吉首大学学报(自然科学版)Vol.35No.12014年1月JournalofJishouUniversity(NaturalScienceEdition)Jan.2014ArticleID:10072985(2014)01002005∗StatisticAnalysisofEfficacyofSOKI-MTinLoweringLead1,CAIFengjing2,QIWeiyun1LIUXingdong(1.CollegeofMathematicsandInformationScience,Z
2、haoqingUniversity,Zhaoqing526061,GuangdongChina;2.CollegeofMathematicsandInformationScience,WenzhouUniversity,Wenzhou325035,ZhejiangChina)Abstract:Inthispaper,byone-samplekolmogorov-smirnovtest,pairedsamplesT-testandspearmanrankcorrelationcoefficienttest,th
3、eauthorsanalysethedataof200casesofchildrenleadpoisoningbeforeandafterthetreatmentofSOKI-MT.Theresultsshowthatthecontentofleadinthechildrenisgettinglow-erobviouslyaftertheytookSOKIMT.Keywords:leadreduction;effect;statisticanalysis;one-samplekolmogorov-smirno
4、vtest;T-test;rankcor-relationCLCnumber:O212Documentcode:ADOI:10.3969/j.issn.10072985.2014.01.0061IntroductionLeadisoneoftheheavymetalsandapoisonoussubstancetoanimals.Inorganicleadismainlytakeninthroughingestionandinhalation.Bloodisoneofthemainbodycompartmen
5、tsthatstorelead.Itdeliv-ersleadintoorgansandtissues,sothatleadcanbindtovarioussulfhydryl-containingaminoacidsonmanyenzymesandfurtherinterfereenzymaticreactions.Therefore,leadistoxictometabolismandtis-sues,includingheart,bones,intestines,kidneys,andreproduct
6、ive,especiallynervoussystemsandhemesynthesis.Leadaffectsvirtuallyeveryorganorsysteminthebody,andtheproposedmechanismsofleadtoxicityinvolvefundamentalbiochemicalprocesses.Theseproposedmechanismsincludeleadsabilitytoinhibitormimictheactionofcalciumandtointera
7、ctwithproteins.Oneofthebestdocumentedmecha-nismsisimpairmentofhemesynthesiswhichresultsinadverseeffectsnotlimitedtothehematopoietic[1]system.Mostoftheleadinbloodisboundtoerythrocytesbutplasmaisthebiologicallyactivecom-[2]partmentfromwhichleadisavailabletocr
8、osscellmembranes.Moreover,leadpoisoningpossesseshavemoresevereeffectsonchildren,especiallyontheirmentalandbodydevelopmentforleadcancauseirreversibledamageonbrain,resultinginpermanentnervedam-age.Childr
