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1、放射免疫学杂志2005年第18卷第1期JofRadioimmunology2005,18(1)—21—效治疗后血浆活性因子趋向正常水平,明显区别于治疗前结[4]MorelliS,FerriC.Circulatingendothelin-1levelsinsystemicscle2果;而其余患者则无明显变化。由此可见,血管内皮细胞活rosissubsets-αmarkeroffibrosisorvasculardysfunction?JRheumatol.性因子的检测有助于探讨凯时治疗SSc的作用机制,并可作1996A,23(4):789.[5]TakahashiH,HarkerLA.Measu
2、rementofhumanendothelialcellsin为判断治疗疗效的实验室指标。wholeblood.ThrombRes.1983,31:1.[6]MarchesiS,PasqualiniL,LombardiniR,etal.ProstaglandinE1参考文献improvesendothelialfunctionincriticallimbischemia.JCardiovascPhar2[1]中华风湿病学杂志编辑部1系统性硬皮病分期标准1中华风湿macol.2003,41(2):249.病学杂志11998,2:661[7]WeissT,GriesshaberJ,RogattiW
3、,etal.ProstaglandinE1incriti2[2]张本法1山莨菪碱治疗系统性硬皮病1中华皮肤科杂志11995,callimbischemiatranscutaneousPO2:apredictorofefficiency.Angiolo228(5):3261gy.1994,3(2):97.[3]李凡,阿曼古力,阿不里克木江,等1维吾尔药椎果腾治疗硬皮病(2004-11-29收稿)6例1中华皮肤科杂志11997,30(1):531血清胃蛋白酶原与胃泌素检测对消化性溃疡病的诊断价值北京市房山区第一医院(102400)肖占森李景荣冯建东王玉琼付秀峰张兰风摘要目的:探讨胃、十二指肠溃疡患
4、者血清胃蛋白酶原(PG)、胃泌素(GS)水平变化规律及临床意义。方法:采用免疫放射分析测定了100例正常人,61例十二指肠球部溃疡,46例胃溃疡患者,66例胃癌和101例慢性胃炎患者血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、GS含量及PGⅠ/PGⅡ比值变化。结果:十二指肠溃疡组和胃溃疡组PGⅠ、PGⅡ、PGⅠ/PGⅡ较对照组显著增高(P<01001),GS水平较对照组、慢性胃炎组明显增高(P<01001),但明显低于胃癌组(P<01001),十二指肠球部溃疡组PGⅠ、PGⅠ/PGⅡ水平较胃溃疡组明显增高(P<01001)。结论:过高的PGⅠ、PGⅡ、PGⅠ/PGⅡ、GS水平增高是溃疡
5、病的高危因素之一,作为一项血清学指标,对溃疡病的诊断及疗效观察有重要的临床意义。关键词胃溃疡十二指肠溃疡胃蛋白酶原胃泌素DiagnosticValueofDeterminationofSerumPepsinogenandGastrinLevelsinPatientswithPepticUlcerXiaoZhansen,LiJingrong,FengJiandong,etal.TheFirstPeople’sHospitalFangshanDistrict,Beijing(102400)AbstractObjectiveToinvestigatetheclinicalsignificanceof
6、changesofserumpepsinogenandgastrinlevelsinpatientswithgastric/duodenalulcer.MethodsSerumpepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),gastrinlevelsandPGⅠ/PGⅡratioweredeterminedwithRIAin100controls,61patientswithduodenalulcer,46patientswithgastriculcer,66patientswithgastriccancerand101patientswithchronicgastriti
7、s.ResultsInpatientswithpepticulcer(gastric/duodenal),theserumlevelsofPGⅠ,PGⅡandPGⅠ/PGⅡratioweresignificantlyhigherthanthoseincontrols(P<0.001);theserumgastrinlevelswerealsosignificantlyhigherthanthose
