玻璃酸钠联合复方倍他米松治疗膝骨关节炎44例临床观察.doc

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1、玻璃酸钠联合复方倍他米松治疗膝骨关节炎44例临床观察2018-11-1501:27:10风湿病与关节炎2018年8期杜立群【摘要】目的：观察玻璃酸钠联合复方倍他米松治疗膝骨关节炎的临床疗效。方法：将88例膝骨关节炎患者随机分为治疗组和对照组，每组44例。对照组给予玻璃酸钠关节腔内注射，治疗组在对照组治疗基础上加用复方倍他米松关节腔内注射。观察2组临床疗效，以及治疗前后视觉模拟评分法(VAS)评分、美国特种外科医院膝关节评分(HSS评分)，治疗过程中药物不良反应情况。结果：治疗组显效14例，有效26例，无效4例，总有效率为90.91%：对

2、照组显效10例，有效20例，无效14例，总有效率为68.18%。2组比较，差异有统计学意义(Pv0.05)。治疗7d后，2组VAS评分较治疗前均有降低，且治疗组低于对照组(P<0.05)。治疗5周后，2组HSS评分较治疗前均有升高，且治疗组高于对照组(P<0.05)。2组患者治疗期间均未发生明显药物不良反应。结论：玻璃酸钠联合复方倍他米松关节腔内注射治疗膝骨关节炎疗效显著，可以有效提高患者膝关节功能，缓解疼痛程度，且安全性较高。【关键词】骨关节炎，膝；玻璃酸钠；复方倍他米松；临床疗效ClinicalObservationon44Case

3、sTreatedwithSodiumHyaluronateCombinedwithCompoundBetamethasoneDULi-qun[ABSTRACT]Objective：Toobservetheclinicalefficacyofsodiumhyaluronatecombinedwithcompoundbetamethasoneinthetreatmentofkneeosteoarthritis.Methods：Eighty-eightpatientswithkneeosteoarthritiswererandomlydivi

4、dedintoatreatmentgroupandacontrolgroup,44casesineachgroup.Thecontrolgroupwasgivenintra-articularinjectionofsodiumhyaluronate,andthetreatmentgroupwasgivenintra-articularinjectionofcompoundbetamethasoneonthebasisofthetreatmentforthecontrolgroup.Theclinicalefficacy,visualan

5、aloguescale(VAS),HospitalforSpecialSurgeryKneeScore(HSS)andadversedrugreactions(ADR)wereobservedbeforeandaftertreatment.Results：Inthetreatmentgroup,14casesweremarkedlyeffectiver26caseswereeffective,4caseswereineffective,andthetotaleffectiveratewas90.91%,whileinthecontrol

6、group,10casesweremarkedlyeffective,20caseswereeffective,14caseswereineffectiveandthetotaleffectiveratewas68.18%.Thedifferencebetweenthetwogroupswasstatisticallysignificant(P<0.05)・After7daysoftreatment，theVASofthetwogroupswaslowerthanthatbeforetreatment，andthatofthetreat

7、mentgroupwaslowerthanthecontrolgroup(P<0.05).After5weeksoftreatment,theHSSofthetwogroupswashigherthanthatbeforetreatment,andthatofthetreatmentgroupwashigherthanthecontrolgroup(P<0.05).Noobviousadversereactionswereobservedinthetwogroupsduringtreatment.Conclusion：Intra-art

8、icularinjectionofsodiumhyaluronatecombinedwithcompoundbetamethasoneiseffectiveinthetreatmentofkneeosteo