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时间:2020-05-15
《脐血干细胞移植结合补益肾气利湿法对ChildA、B级肝硬化患者免疫功能的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、J考用临床医药母志2014年第18卷第19期·38·ourna1ofClinicalMedicinei12Practice’’一。’脐血干细胞移植结合补益肾气利湿法对ChildA、B级肝硬化患者免疫功能的影响周晓玲,谢胜,陈峭,侯秋科(广西壮族自治区柳州市中医院消化科,广西柳州,545001)摘要:目的探讨脐血干细胞移植联合补益肾气利湿法治疗ChildA、B级肝硬化的疗效,及其对患者免疫功能的影响。方法选择ChildA、B级肝硬化患者50例,随机分为治疗组和对照组,各25例。对照组采用脐血干细胞移植法治疗,治疗组在此基础上联合补益肾气利湿法进行综合治疗。2组患者分别于治疗前及治
2、疗后检测T淋巴细胞亚群、红细胞免疫功能,并于治疗后第12个月复行肝组织病理学检查。结果治疗前后,2组CD4T细胞百分比、CD8T细胞百分比、CD4T/CD8T、红细胞C3b受体黏附花环率(RBC3bRR)、红细胞免疫复合物花环率(~dCR)、红细胞免疫黏附促进率(RFER)、红细胞免疫黏附抑制率(RFIR)、肝组织病理学检查等相关指标均有显著差异(P<005或P<0.01),且上述指标组问两两比较具有显著统计学意义(P3、的作用。关键词:脐血干细胞移植;补益’肾气利湿法;肝硬化;红细胞免疫;T细胞亚群中图分类号:R657.3文献标志码:A文章编号:1672—2353(2014)19—038-03IX)I:10.7619/jcmp.201419012Influenceofumbilicalcordbloodstemcelltransplantati0ncombinedwiththerapyofinvigoratingkindneyqitoremovedampnessonimmunefunctionofpatientswithChild—PughAandBcirrhosisZHOUXiaoling,4、XIESheng,CHENQiao,HOUQiuke(DepartmentGastromzterology,LiuzlwuHospital’TraditionalChineseMedicine,L“zh0“.Guangxi,545001)ABsTRACT:ObjectiveToexploretheclinicalefficacyofumbilicalcordbloodstemcelltrans—plantationcombinedwiththerapyofinvigoratingkidneyqitoremovedampnessonpatientswithChild-PughAa5、ndBcirrhosisanditsinfluenceonimmunefunction.MethodsAtotalof50pa—tientswithChild。。PughAandBcirrhosisservedasstudyobjectsandrandomlydividedintotreat—mentgroupandcontrolgroup.25casesforeach.Umbilicalcordblodstemcelltransplantationwaspreformedtocontrolgroupwhiletreatmentgroupaddedwiththerapyofin6、vigoratingkidneyqitoremovedampness.Tcellsubsetiflperipheralbloodanderythrocyteimmunefunctionwastestedbe.foreandafterthetreatment.Pathologyoflivertissuewasexaminedatthe12monthaftertransplan—tation.ResultsThepercentageofCD4TcellSandCD8Tcells,CD4T/CD8T,theredblodcellC3breceptorrosetterate(RBCoC7、3bRR),theredblodcellimmunecomplexrosetterate(RB一(ICR),RFER,RFIR,theinflammationandfibrosisscoresoflivertissuewerestatisticallydiffer—entbeforeandaftertreatmentineachgroup(P<0.05orP<0.01),andtherewerestatisticallysignificanceoftheseindexesbetweenthe
3、的作用。关键词:脐血干细胞移植;补益’肾气利湿法;肝硬化;红细胞免疫;T细胞亚群中图分类号:R657.3文献标志码:A文章编号:1672—2353(2014)19—038-03IX)I:10.7619/jcmp.201419012Influenceofumbilicalcordbloodstemcelltransplantati0ncombinedwiththerapyofinvigoratingkindneyqitoremovedampnessonimmunefunctionofpatientswithChild—PughAandBcirrhosisZHOUXiaoling,
4、XIESheng,CHENQiao,HOUQiuke(DepartmentGastromzterology,LiuzlwuHospital’TraditionalChineseMedicine,L“zh0“.Guangxi,545001)ABsTRACT:ObjectiveToexploretheclinicalefficacyofumbilicalcordbloodstemcelltrans—plantationcombinedwiththerapyofinvigoratingkidneyqitoremovedampnessonpatientswithChild-PughAa
5、ndBcirrhosisanditsinfluenceonimmunefunction.MethodsAtotalof50pa—tientswithChild。。PughAandBcirrhosisservedasstudyobjectsandrandomlydividedintotreat—mentgroupandcontrolgroup.25casesforeach.Umbilicalcordblodstemcelltransplantationwaspreformedtocontrolgroupwhiletreatmentgroupaddedwiththerapyofin
6、vigoratingkidneyqitoremovedampness.Tcellsubsetiflperipheralbloodanderythrocyteimmunefunctionwastestedbe.foreandafterthetreatment.Pathologyoflivertissuewasexaminedatthe12monthaftertransplan—tation.ResultsThepercentageofCD4TcellSandCD8Tcells,CD4T/CD8T,theredblodcellC3breceptorrosetterate(RBCoC
7、3bRR),theredblodcellimmunecomplexrosetterate(RB一(ICR),RFER,RFIR,theinflammationandfibrosisscoresoflivertissuewerestatisticallydiffer—entbeforeandaftertreatmentineachgroup(P<0.05orP<0.01),andtherewerestatisticallysignificanceoftheseindexesbetweenthe
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