妊娠期糖尿病与血糖正常孕妇胰岛素抵抗及胰岛β细胞功能比较.pdf

《妊娠期糖尿病与血糖正常孕妇胰岛素抵抗及胰岛β细胞功能比较.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、·2066·JournalofClinicalandExperimentalMedicineVo1．13，No．24Dec．2014DOI：10．3969／j．issn．1671—4695．2014．24．021文章编号：1671—4695(2014)24—2066—03妊娠期糖尿病与血糖正常孕妇胰岛素抵抗及胰岛I3细胞功能比较牟莹莹刘聿秀修霞(山东省潍坊市妇幼保健院VIP产科山东潍坊261011)【摘要】目的对比观察妊娠期糖尿病(GDM)与血糖正常孕妇胰岛素抵抗及胰岛13细胞功能。方法选择187例有GDM危险

2、因素的产妇进行前瞻性研究，于早孕期和中孕期进行口服葡萄糖耐量试验(OGTF)检查，根据OGqT结果分为GDM组(86例)和非GDM组(对照组，101例)。检测两组胰岛素水平，采用稳态模型评估胰岛素抵抗指数(HO—MA—IR)、胰岛13细胞功能指数(HOMA—p)，计算早期胰岛素分泌指数(AI。／AG。)、混合胰岛素敏感度(ISIcomp)并比较。结果GDM组早孕期、中孕期的HOMA—IR显著高于对照组，AI／AGISIcomp显著低于对照组。与早孕期相比，中孕期对照组和GDM组的HOMA—IR显著高于早孕期，A

3、I。／AG30、ISIcomp显著低于早孕期。结论GDM患者早孕期就存在明显的胰岛素抵抗。应进行严格管理，控制血糖，保护胰岛B细胞功能，从而改善妊娠结局。【关键词】妊娠期糖尿病胰岛素抵抗胰岛B细胞Thecomparisonofinsulinresistanceandpancreatic13一cellfunctioninnormalpregnantwomenandgestationaldiabetesmdUtus．MOU一ng，LIUYu—xiu，XIUXia．DepartmentofVIPObstetrics，

4、MaternalandChildrenHealthHospitalofWeifang，WeifangShandong26101l。China．【Abstract】0bjectiveTocompareofinsulinresistanceandpancreaticB—cellfunctioninnormalpregnantwomenandgestationaldiabe-tesmellitus．Methods187easesofpregnantwomenwithriskfactorsforGDMwascollec

5、tedinprospectivestudy．OGTYwasconductedinearlyandmiddlepregnancyandinsulinlevelwasdetected．Homeostasismodelassessmentforinsulinresistanceindex(HOMA—IR)andpancreaticB—cellfunctionindex(HOMA—p)wascalculated．Earlyinsulinsecretionindex(AI30／AG30)，mixedinsulinsens

6、itivity(ISIcomp)werecalcu—latedandcomparedbetweenthetwogroups．ResultsIntheGDMgroup，wefound86casesincontrolgroup，wefound101casesinpregnantwomen．InearlyandmiddlepregnancyinGDMgroup，HOMA—IRwassignificantlyhigher，AI30／AG30，ISIcompsignificantlylowerthanthecon—tro

7、lgroup．Comparedwithearlypregnancy．HOMA—IRinGDMgroupandthecontrolgroupinmiddlepregnancywassignificantlyhigherthanthatofearlypregnancy．AI30／AG30，ISIcompwassignificantlylowerthanthatofearlypregnancy．ConclusionInpregnantwomenwithgestationaldiabetesduringearlypre

8、gnancy，thereisasignificantinsulinresistance．Weshouldstrictlymanageandcontrolfastingglucose，protectisletB—cellfunction，andtherebyimprovingpregnancyoutcomes．【Keywords]Gestationaldiabetes；Insulinre