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时间:2020-05-24
《非酒精性脂肪性肝炎与内皮功能异常和动脉粥样硬化的关系.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华肝脏病杂志2014年3月第22卷第3期ChinJHepatol,March2014,Vo1.22,No.3·205·非酒精性脂肪性肝炎与内皮功能异常和动脉粥样硬化的关系曹一显李良平I摘要】目的探讨青中年非酒精性脂肪性肝炎(NASH)与动脉内皮功能和动脉粥样硬化(AS)的关系,为预测和预防NASH患者AS提供临床依据。方法根据51例非酒精性脂肪性肝病患者的组织学特征分为NASH组40例和单纯非酒精性脂肪肝(NAFL)组11例。进行常规人体学指标检测、血液生物化学和代谢指标测定,计算胰岛素抵抗稳
2、态模型指数。酶联免疫吸附法检测血清超敏C一反应蛋白、可溶性细胞间黏附分子一1、内皮素一1;并用彩色超声诊断仪检测颈动脉内膜中层厚度,动脉硬化测定仪检测臂踝脉搏波传导速度和踝臂指数。组间数据比较采用检验或秩和检验。结果超敏C一反应蛋白在NASH组为3.69(2.56,6.48)mg/L,高于NAFL组的1.47(1.34,2。40)mg/L,=-3.962,尸<0.01,可溶性细胞间黏附分子一1在NASH组和NAFL组分别为(624.78土40.12)ng/ml和(464.49土24.81)ng/
3、ml,t=-12.552,P<0.01;内皮素一1在两组分别为67.57(66.58,7O.42)pg/ml、58.00(55.46,61.28)pg/ml,Z=-4.237,尸<0.01。比较NASH组与NAFL组颈动脉内膜中层厚度[0.900(0.850,0.990)mm与0.075(0.070,0.080)mm]、臂踝脉搏波传导速度[1505.75(1377.90,1583.80)cm/s与1390.50(1306.5O,1416.00)cm/s],值分别为-4.419和-2.199,P值
4、均<0.05。胰岛素抵抗稳态模型指数NAsH组(1.95土0.84)明显高于NAFL组(1.25士0.40),=3.888,尸<0.01。结论非酒精l兰E脂肪肝患者肝脏炎症与动脉内皮功能紊乱和AS密切相关,对青中年脂肪肝患者应及早积极干预以预防心脑血管疾病。【关键词J脂肪肝;动脉内皮功能;动脉粥样硬化RelaUonshipofnon-alcoholicsteatohepatifiswitharterialendothelialfunctionandatherosclerosisCoocHLiLi
5、an~ing.DepartmentofGastroenterology,SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHospital,Chengdu61oo72,ChinaCorrespondingauthor:LiLian~ing,Email:llpO131@medmail.com.cn[Abstract]OMeetiveTostudytherelationshipbetweennon-alcoholicsteatohepa
6、titis(NASH)andatherosclerosisinyoungandmiddle-agedpatients,andtoprovideclinicalevidencethatwillaidinpreventionandpredictionofdevelopmentofatherosclerosisorcardiovasculardiseasesinpatientswithnon-alcoholicfattyliverdisease(NAFLD).MethodsFifty-onepatie
7、ntswithbiopsy-provenNAFLDf18t060yearsinage)weredividedintotwogroups:caseswithsimplenon—alcoholicfattyliver(NAFL./1=I1)andcaseswithNASH=40).Allsubjectsunderwentphysicalexaminationandanthropometricmeasurements.Fastingserumwasassayedbybloodbiochemistry.
8、Insulinresistancewasestimatedbythehomeostaticmodelassessmentindex(HOMA—IR).Serumlevelsofhigh-sensitivityC-reactiveprotein(hs—CRP),solubleintercellularadhesionmolecule一1(sICAM-1),andendothelin-1(ET-1)weredetectedbyenzyme-linkedimmunosorbentassay.Carot
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