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时间:2020-09-06
《回旋加速器放射性药物生产场所的防护设计与分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、首都公共卫生2013年2月第7卷第1期CapitalJournalofPublicHealth,Feb.2013Vol.7No.1·7·中图分类号:R812文献标识码:A文章编号:1673-7830(2013)01-0007-07·论著·回旋加速器放射性药物生产场所的防护设计与分析马永忠万玲娄云张泓李慧娟孟庆华王宏芳冯泽臣【摘要】目的掌握回旋加速器放射性药物生产场所的辐射危害因素及其水平,为场所的防护设计和放射性药物生产的放射防护提供指导。方法以某医院引进的1台HM-20S型回旋加速器及其药物生产场所为研究对象,依据国家有关法规和技术标准确定场所中的辐射危害因素类别及场所级别,对相应
2、的防护设施与措施进行分析和评价。结果制订出放射性药物生产场所的辐射防护设计方案,其中对热室工作区出入口采取GMP(良好作业规范)设计;估算出18了控制区外围和场所关注点的辐射水平,在60mmPb厚壁工作箱内进行222GBq的F操作时,操作位置的剂量率为9.6μSv/h;明确了回旋加速器机房内活化产物的来源及其防护措施;带有自屏蔽的回旋加速器运行时,机房内的O浓3度远低于标准规定的职业接触限值。结论该放射性药物生产场所的防护设计充分考虑了放射性污染和外照射的防护,但其防护方案中还需对回旋加速器机房及防护门的屏蔽设计进行优化。【关键词】回旋加速器;放射性药物;生产场所;辐射防护;防护设计
3、ProtectiondesignandanalysisontheproducingworkplaceofradiopharmaceuticalmanufacturedbycyclotronMAYong-zhong,WANLing,LOUYun,ZHANGHong,LIHui-juan,MENGQing-hua,WANGHong-fang,FENGZe-chen(BeijingCenterforDiseaseControlandPrevention,Beijing100013,China)【Abstract】ObjectiveTounderstandtheradiationhazard
4、factoranditslevelinradiopharmaceuticalproductionsitesbycyclotron,soastoprovideguidanceforradiationprotection.MethodsAcyclotrontypedHM-20Sanditsworkplace,whichbelongedtoahospital,werestudiedastheobject.Theclassificationofradiationhazardfactorsandgradeoftheworkplacewereconfirmedaccordingtotherela
5、tivenationalregulationsandtechnologicalstandards.Therelatedprotectionfacilitiesandmeasureswereanalyzedandassessedatthesametime.ResultsTheprojectofradiationprotectionwasformulatedforcommissioningoftheradiopharmaceuticalproducingworkplace,andtheentrancecompartmenttohotareawasdevisedinGMP(GoodManu
6、facturingPractice)plan.Theradiationlevelofoutsidecontrolledareasandfocuspointsintheworkplacewerecalculated.18Themaximumwas9.6μSv/honthemanipulationlocationwhile222GBqofFwasoperatedintheworkboxwith60mmPb.Thesourceofactivatedproductswasdiscoveredandsomeprotectionsuggestionswereclaimed.Theconcentr
7、ationlevelofOinthe3acceleratorroomwasmuchlowerthantheoccupationallimit,whichrestrictedinthecriterion,whilethecyclotronwithself-shieldingwasrunning.ConclusionTheprotectionmeasuresforbothradioactivecontaminationandexternalradiationw
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