中山大学-高雄医学大学.ppt

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1、中山大學-高雄醫學大學跨領域學術合作會議高雄醫學大學附設醫院小兒科林龍昌醫師EffectofMusicondevelopingbrainOutlineMusicandneuronalplasticityMusicandneurotransmitterMedicalapplicationofmusicResearchaimMusicandneuronalplasticityAnn.N.Y.Acad.Sci2009MusicandneuronalplasticityMIDI-pianoorelectronicdrum

2、padsfor3weeksenhancefineandgrossmotorrecoveryaswellaselectrophysiologicalchangesin32patientsofstroke.Thissuggeststhatmusic-makingmightbeaneffectivemeanstoinduceplasticchangesinthemotorsystem.Ann.N.Y.Acad.Sci2009Investigatestructuralbrainchangesinrelationtobehav

3、iorchangesinyoungchildrenwhoreceived15monthsofinstrumentalmusicaltraining.Instrumentalchildrenshowedimprovementonfingermotortaskandthemelody/rhythmictasks.ClinicalMedicine2008Lengthofprecentralgyrusislongerinkeyboardplayersrelativetonon-musiciancontrols.Profess

4、ionalmusicianswhocommencedtheirtrainingbeforeagesevenwerefoundtohavealargeranteriorportionofthecorpuscallosumcomparedtonon-musiciancontrols.MusicandneurotransmitterNeuroscienceletters2007GluR2,amajorsubunitinAMPAreceptor,participateinplasticchangesintheefficacy

5、ofsynaptictransmissionunderlyinglearning,memory,andformationofneuralnetworks.Brainresearch2007Fertilizedeggsofchickswereexposedtoeitherspecies-specificcallsorsitarmusicat65dBfor15min/hroundtheclockfromembryonicday10untilhatching.Hippocampusofdevelopmentalstages

6、(E12,E16,andE20)wereexamined.Thehippocampusshowedanincreaseinitsvolume,totalnumberofneuronsandlevelsofexpressionofcalbindinD-28Kandparvalbumin.CalbindinD-28Kandparvalbuminarethemarkersofneuronaldifferentiationandoutgrowth.Prenatalauditorystimulationaltersthelev

7、elsofCREB(cyclic-AMPresponseelementbindingprotein)mRNA,p-CREBandBDNFexpressioninchickhippocampus.Enhancedproteinexpressionsmayberesponsibleforneuronalplasticity.Prenatalauditorystimulationincreasedexpressionofsynapticproteins,c-fos,c-jun.Medicalapplicationofmus

8、icResearchaimPrenatalmusicexposureonthechangeofneurotransmitterandbehaviorinratEffectofmusictherapyonthehypoxicpuprat參與研究成員與工作分配中山大學莫顯蕎老師、魏瑞昌老師:音樂轉換與分析中山大學李美文老師、翁佳芬老師:音樂選擇高雄