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1、自身防御机制IMMUNERESPONSE3rdLineofdefense:ImmuneResponseSlower&specificcomparedtoinflammatoryresponseInflammatory&immuneresponsescomplementeachother&interactincomplexwaysTHEIMMUNESYSTEMExtraordinarycomplexsystemElaborate&dynamiccommunicationnetworkRecognizes&respondstoantigensCells&mol
2、eculesoftheimmunesystemprotectthenosefromattackbyavirusCHARACTERISTICS OFIMMUNERESPONSEImmunityStateofprotection,primarilyagainstinfectionsCharacterizedbymemory&specificityAntigensChemicalsubstancesthatreactwithpreformedcomponentsoftheimmuneresponseImmunogensAntigensthatinduceanim
3、muneresponseHaptensAntigensmustbeboundtocarrierstoinduceanimmuneresponseSelf-AntigensAntigensonhostcellsNotrecognizedasimmunogenicbyhost’simmunesystemAconditioncalledtoleranceCHARACTERISTICS OFIMMUNERESPONSEINDUCTIONOFIMMUNERESPONSEMostimmunesystemcellsareWBCsImmunocytes(lymphocyt
4、es)are1typeofWBC2majorclassesofimmunocytesTlymphocytes(Tcells)&Blymphocytes(Bcells)ImmuneresponseischaracterizedbytheactivationofBcells&TcellsBCELLSDevelopsfromastemcellthatmaturesunderhormonalcontrolinbursal-equivalenttissues(bonemarrow)Developsintoamatureplasmacellcapableofprodu
5、cingantibodyagainstaspecificantigenAntibodymarkstheantigenfordestructionbyotherimmunecellsANTIBODIESPlasmaglycoproteinsClassifiedbychemicalstructure&biologicactivityIgG,IgM,IgA,IgE,orIgDProtecthostfromharmfulantigensRecognizeandbindwithantigensFunctions:Opsonizebacteria,neutralize
6、toxins&virusesActivatesinflammatoryresponseANTIBODYCLASSIFICATIONIgG–80%plasmaIg,inallbodyfluids,secondaryresponse,activatescomplementIgM–Primaryresponse,largemolecule,vascularsystem,activatescomplementIgA–95%ofbodysecretionIg,respiratoryandGItract,coatsbacteria&somevirusesIgD–Pla
7、sma,Bcellsurfaces,antigenreceptorIgE–Hypersensitivityandallergicreactions(asthma)DevelopfromstemcellsthatmatureunderhormonalcontrolinthymusMakeupthecell-mediatedimmuneresponseHelptodestroyinfectedcellsCoordinatetheoverallimmuneresponseTCELLSTYPESOFTCELLSCytotoxicTcellsKilltargetce
8、llsdirectlyDelayedhypersensitivit
