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ID:11224365
大小:435.50 KB
页数:24页
时间:2018-07-10
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1、HowtoWritetheIntroductionS1020489王华斌S1010133陈方城S1010104张李巧Thispptconcludes:definitionandpurpose(定义)rulesforagoodIntrodutionandsomeexceptions(好的引言的原则和例外).reasonsfortherules(原则的解释).tense(时态).people(人称).citationandabbreviations(引用和缩写).definitionandpurposeThefirstsectionofthetextSupplysuf
2、ficientbackgroundinformation(背景知识)toallowthereadertounderstandandevaluatetheresultsofthepresentstudyPrevioustherationale(原理)forthepresentstudyandyourpurpose(目的)inwritingthepaper.RulesforagoodIntrodutionpresentfirst,withallpossibleclarity,thenatureandscopeoftheprobleminvestigated(主题).B
3、rieflyreviewthepertinentliteraturetoorientthereader(背景).Statethemethodoftheinvestigation.ifdeemednecessary,thereasonsforthechoiceofaparticularmethodshouldbestated(方法和原因).Statetheprincipalresultsoftheinvestigation(结果).Statetheprincipalcnclusionsofsuggestedbytheresults(结论).ExampleTheblo
4、odbrainbarrier(BBB)formedbytightendothelialcelljunctionsofbraincapillarypreventsalargenumberoftherapeuticcompoundsfromcentralnervoussystem(CNS),includingantibiotics,antineoplasticagentsandCNSactivedrugs.Methotrexate(MTX)isapromisingantitumordrug.Unfortunately,itisverydifficultforMTXto
5、penetrateBBBsothattheadministrationofintrathecalinjectionisemployedinclinicaltreatmentforbraintumors.However,thisroutesubjectspatientstooperationwoundsandhighrisks.介绍研究领域及其一般进展,提供背景资料背景:以前研究中存在的问题ExampleSeveralpharmaceuticalmethodshavebeentriedtoovercomeBBB.First,drugswithproperchemic
6、alstructurescanbemodifiedtoenhancebrainuptakeusuallybyintroductionoflipophilicgroups.Besides,anovelchemicaldeliverysystemhasalsodeveloped(Yoshikawaetal.,1999).However,thisstrategyislargelylimitedbythechemicalstructureofcompounds.Atthesametime,alargenumberoflipophiliccompoundsthatcanpa
7、ssthroughBBBarerapidlypumpedbackintobloodstreambymulti-drugresistanceproteins(MRPs)includingmultipleorganicaniontransporter(MRP2)andP-glycoprotein(Pgp).Theexistenceofsucheffluxpumpsprovestobeanotherlimitationtothismethod.Second,stericallystabilizedimmunoliposomesareusedforbothchemical
8、drugs
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