牙齿、腮腺等口腔常见疾病的诊治分析 (10)

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1、动脉化疗前后MMP9、TIMP1在口腔鳞癌组织中的表达作者：李雅冬,张劲松,杨凯,张福军,陈睿,邓丹作者单位：(重庆医科大学附属第一医院口腔科,重庆400016)【摘要】目的：研究MMP9、TIMP1在化疗前后口腔鳞癌组织中的表达，探讨口腔鳞癌的侵袭机制。方法:应用免疫组织化学SP法检测化疗前后MMP9和TIMP1在口腔鳞癌组织中的表达，分析不同临床分期、组织学分级、淋巴结有无转移间的MMP9及TIMP1表达是否存在差异，结合临床病理资料和基因蛋白表达特征作差异显著性检验及相关分析。结果:化疗前口腔鳞癌MMP9表达高于化疗后，MMP9表达与临床分期，淋

2、巴转移和疗效有关,与组织学分级，性别和年龄无关;化疗前后TIMP1表达无差异，TIMP1表达与临床分期，淋巴转移和疗效有关，与分级，性别和年龄无关;MMP9与TIMP1阳性率密切负相关(r=-0.54368,P<0.05)，化疗前后MMP9和TIMP1与疗效之间密切负相关(r=-0.60947,P<0.05)。结论:MMP9及其抑制因子TIMP1在口腔鳞癌的进展过程发挥重要作用，综合分析上述基因蛋白表达特征和口腔鳞癌的临床-病理特点可较好地指导治疗。【关键词】口腔肿瘤;癌，鳞状细胞;基质金属蛋白;金属蛋白酶1组织抑制剂;化学栓塞，治疗性Expression

3、ofMMP9andTIMP1inOralSquamousCellCarcinoma　　beforeandafterReceivedIntraarterialChemotherapy　　LIYadong,ZHANGJinsong,YANGKai,ZHANGFujun,CHENRui,DENGDan　　(DepartmentofStomatology,TheFirstAffiliatedHospital，Chongqing　　UniversityofMedicalScience,Chongqing,400016,China)　　[Abstract]Objective:To

4、investigatetheexpressionofMMP9andTIMP1inoralsquamouscellcarcinoma(OSCC)beforeandafterintraarterialchemotherapy(IC),andtoexploretheinvasivebehavior,mechanism,andprognosisofOSCC.Methods:Specimensof20OSCCpatientsbeforeandafterICwereexaminedbyusingSPimmunohistochemistrymethod.Theexpressionc

5、haracteristicsofMMP9andTIMP1,andclinicalandpathologicalfeaturesweredeterminedanddifferenceswereanalyzed.Results:MMP9expressioninOSCCwashigherbeforeICthanafter,andsignificantlyrelatedwithclinicalstages,lymphnodemetastasis,andcurativeeffect,butnotwithhistologicalgrades,orsexandageofpatie

6、nts;TIMP1expressionbeforeICdidnotdifferfromthatafter.ThereweresignificantcorrelationsofTIMP1expressioninOSCCwithclinicstages,lymphnodemetastasis,andcurativeeffect,butnotwithhistologicalgrades,orsexandageofpatients;AsignificantlynegativecorrelationwasobservedbetweenMMP9positivestainning

7、andTIMP1positivestaining(r=-0.54368,P<0.05),andtherewasacloselynegativecorrelationbetweenMMP9andTIMP1expressionwithcuritiveeffectsofIC(r=-0.60947,P<0.05).Conclusions:MMP9anditsinhibitoryfactorTIMP1mayplayakeyroleinprogressofOSCC.Analysisoftheexpressioncharacter