资源描述：
《oxidative stress-induced cellular senescence》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、OxidativeStress-inducedIntroductoryarticleCellularSenescenceArticleContents.IntroductionOlivierToussaint,UniversityofNamur,Namur,Belgium.OxidativeStress-inducedPrematureSenescence:ExperimentalProtocolsJose´Remacle,UniversityofNamur,Namur,Belgium.CellularandMolecularMec
2、hanismsofStress-inducedPatrickDumont,UniversityofNamur,Namur,BelgiumPrematureSenescence.UVRadiation-andCholeraToxin-inducedPrematureJean-Franc¸oisDierick,UniversityofNamur,Namur,BelgiumSenescenceinHumanMelanocytesThierryPascal,UniversityofNamur,Namur,Belgium.Cytokine-i
3、nducedPrematureSenescenceTriggeredbyInterleukin1aandTumourNecrosisFactorChristopheFrippiat,UniversityofNamur,Namur,Belgium.RoleofEnergeticsintheResistancetoSIPSJoaoPedroMagalhaes,UniversityofNamur,Namur,Belgium.InvitroAlternativeToxicologicalMethodforTestingLong-termEf
4、fectsofXenobioticsFlorenceChainiaux,UniversityofNamur,Namur,Belgium.ConclusionandTheoreticalImplications.SummaryReplicativesenescenceisaprocessinwhichnormalproliferativecellslosereplicativepotentialandacquirebiomarkersofcellularsenescenceasaresultofserialpassagesincult
5、ureinsteadofchronologicaltime.Oxidativestress-inducedprematuresenescenceisthelong-termappearanceofthebiomarkersofreplicativesenescenceafterexposureofhumandiploidcellstosublethalstress.Cytokine-inducedprematuresenescenceisthelong-termappearanceofbiomarkersofreplicatives
6、enescenceafterrepeatedexposureofhumandiploidfibroblaststoproinflammatorycytokines.Introductiondamageintheirdeoxyribonucleicacid(DNA),proteinsandlipids.TransgenicoverexpressionofantioxidantDespitethefactthathumanmortalityrateincreaseswithenzymessuperoxidedismutaseandcat
7、alaseprolongtheage,ageingperseisrarelyacauseofdeathinhumans.lifespanofDrosophilaflies.However,thequestionofhowInstead,ageingresultsinanincreasedriskofdevelopingROScauseageingorageing-associatedchangesinhumanslife-threateningdiseases,suchasarthritis,osteoporosis,remainsu
8、nsolved.Replicativesenescenceofhumanneurodegenerativediseases,etc.Longevitycomparisondiploidfibroblasts(HDFs)hasbeenus
