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1、TheEFSAJournal(2008)674,1-661UseoflycopeneasafoodcolourScientificOpinionofthePanelonFoodAdditives,Flavourings,ProcessingAidsandMaterialsinContactwithFood(QuestionsNoEFSAQ-2007-001,Q-2007-081,Q-2008-076)Adoptedon30January2008PANELMEMBERSFernandoAguilar,HermanAutrup,SueBarlow,Lauren
2、ceCastle,RiccardoCrebelli,WolfgangDekant,Karl-HeinzEngel,NatalieGontard,DavidGott,SandroGrilli,RainerGürtler,JohnChr.Larsen,CatherineLeclercq,Jean-CharlesLeblanc,F.XavierMalcata,WimMennes,MariaRosariaMilana,IonaPratt,IvonneRietjens,PaulTobback,FidelToldrá.SUMMARYFollowingarequestfr
3、omtheCommission,thePanelonFoodAdditives,Flavourings,ProcessingAidsandMaterialsinContactwithFoodwasaskedtodeliverascientificopiniononthesafetyinuseofsyntheticlycopeneasafoodcolourforuseinthefoodcategoriesspecifiedinthedossier.TheScientificPanelonFoodAdditives,Flavourings,ProcessingA
4、idsandMaterialsinContactwithFoodhasalsobeenaskedtoevaluatethesafetyinuseoflycopenefromBlakesleatrisporaasafoodcolourinthefoodcategoriesanduselevelsasproposedinthedossier.Inaddition,inviewofthere-evaluationoflycopenefromtomatoeswithinthere-evaluationprogrammeofallfoodcolours,thePane
5、ldecidedtomakeaglobalsafetyassessmentoflycopenefromallsources.Thus,inthepresentopinionthePanelevaluatesthesafetyinuseoflycopenefromdifferentsourcesasafoodcolour.Resultsfromanimalandhumaninterventionstudieswithsyntheticlycopeneortomatoextractaslycopenesourceindicatethatlycopenefromt
6、hesesourcesisbioavailable.ItisexpectedthatlycopenefromB.trisporawhenusedinfoodstuffsofcomparablecompositionwillbebioavailabletoasimilarextentaslycopenefromtomatoes.Thetoxicityofsyntheticlycopenewasinvestigatedinsubchronicandchronictoxicitystudiesinrats,acarcinogenicitystudyandatwo-
7、generationstudyinrats,anddevelopmentaltoxicity1Forcitationpurposes:ScientificOpinionofthePanelonFoodAdditives,Flavourings,ProcessingAidsandMaterialsinContactwithFoodonarequestfromtheCommissiononthesafetyinuseoflycopeneasafoodcolour.TheEFSAJournal(2008)674,1-12.1memberofthePaneldid
8、notparticipateinthediscuss
