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1、山东大学医学院（2006——2007学年第二学期）2004级临床医学七年制药理学期末考试试题（A卷）FINALEXAMNATIONOFPHARMACOLOGYFOR7-YMS-2004题号一二三四五六七总分统分人得分得分评卷人一、选择题：（A型每题0.5分，X型每题1分,共50分）TypeAChoicequestions(onlyoneansweriscorrect)1．Adrugwitht1/23hoursisgivenintravenously,thesteadystateofplasmaconcentrationcanbeexpectedwit
2、hinA．3hrsB．8hrsC．10hrsD．15hrsE．20hrs2．Whichofthefollowingistrueforadrugwhoseeliminationfromplasmashowsfirst-orderkinetics?A.thehalf-lifeofthedrugisproportionaltothedrugconcentrationinplasmaB.theamounteliminatedperunittimeisconstantC.therateofeliminationisproportionaltotheplasma
3、concentrationD.eliminationinvolvesarate-limitingenzymereactionoperatingatitsmaximalvelocityE.aplotofdrugconcentrationversustimeisastraightline3．Adrugeliminatedwithfirst-orderkinetics,theconcentrationofthedruginplasmais200mg/L,at10o’clockinthemorningafteradministrationofasingled
4、ose,thedrugplasmaconcentrationis25mg/L,at10o’clockonseconddaymorning,itst1/2isA．4hB．6hC．12hD．24hE．8h4.Aspirinisaweakacidwith4.5ofpKa,whatpercentageoflipid-solubleformwillbeinthestomachjuicewith2.5ofpH?A.0.99%officiallyestablishedonJuly1,2013,Yibincity,formerlyknownasthebus,inte
5、gratedoriginalrongzhoubuscompanyinYibincityandMetrobuscompany,formedonlyinYibincityofaState-ownedpublictransportenterprises,thecompanyconsistsofoneortwo,thirdDivision.Integrationofpublictransportservicesisnotyetestablished17B.9%C.9.09%D.90.9%E.99.0%5.Inthisgraph，drugsA，BandCare
6、analogs，thenA.AhasagreaterpotencythanBB.AhasagreaterefficacythanCC.BhaslesspotencythanCD.AhasagreaterpotencythanCE.BhasagreaterefficacythanCBAC效应Log剂量6.Whichofthefollowingstatementsiscorrect?A.if10mgofdrugAproducesthesameresponseas100mgofdrugB,drugAismoreefficaciousthandrugB.B.
7、thegreatertheefficacy,thegreaterthepotencyofadrugC.inselectingadrug,potencyisusuallymoreimportantthanefficacyD.acompetitiveantagonistincreasesED50E.variationinresponsetoadrugamongdifferentindividualsismostlikelytooccurwithadrugshowingalargetherapeuticindex7.Amongthefollowingdru
8、gs,whichwillbeexcretedmostquicklyinacidicurine？A.aweak
