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1、UrticariaCHENAijunMDDepartmentofDematology,TheFirstAffiliatedHospital,ChongqingMedicalUniversityDefinitionUrticariaisaverycommondiseaseandisavascularreactionoftheskincharacterizedbytheappearanceofwheals,whiteorredevanescentplaquesgenerallysurroundedbyaredhaloorflareandas
2、sociatedwithsevereitching,stinging,orprickingsensations.Thesearewheals,whiteorredevanescentplaquesgenerallysurroundedbyaredhaloorflare.Fastappearinganddiminishing,notraceafterdiminishing.EtiologyFoodsMedicinesInfectionsPhysicalfactorsAnimalsandplantsSpiritfactorsDiseases
3、ofinternalorgansEtiology1.FoodsThemostallergenicfoodsareshellfish,shrimps,crab,chocolate,nuts,peanuts,tomatoes,strawberries,melons,pork,cheese,garlic,onions,andspices.Eggsandmilkalwaysinduceurticariainchildren.2.MedicinesManymedicinescanstarturticariabyallergy,themostcom
4、mondrugsareasfollows:penicillin,serum,vaccine,furazolidone,sulfanilamideandsoon.Sometimesafewdrugscandirectlystimulatemastcellstoproducehistamine,likeaspirin,morphine,codeine,quinine,etc.3.InfectionsInfectionscausedbyallorganismsareanotherpossiblereasonstoinduceurticaria
5、.Themostcommonorganismisvirusofupperrespiratoryandstaphylococcusaureus.Chronicinfectionsofthepatientscannotbeeasyverifiedasthepathogenofurticaria;itmustbetestedbytherapy.4.Physicalfactors:Cold,hot,sunlight,frictionandpressure5.Animalsandplants:Urticariacanbeinducedbyanim
6、al'sfurskinorpollenorstingingofinsects.6.Spiritfactors:Insomecases,stresscantriggerurticaria,butinanothercasesstressmayleadtohistaminereleasing.7.DiseasesofinternalorgansRheumaticdisorder,rheumatoidarthritis,systemiclupuserythema,malignanttumor,disorderofendocrineandsome
7、otherscanbeanotherreasonsofurticaria.Pathogenesis1.AllergyanaphylactictypeimmunecomplextypeandallergicvasculitisThewhealresultsfromincreasedcapillarypermeability,whichallowsproteinsandfluidstoextravasate.Capillarypermeabilityresultsfromtheincreasedreleaseofhistaminefromt
8、hemastcellssituatedaroundthecapillaries.AllergyThemastcellistheprimaryeffectorcellinurticarialreactions