膝骨关节炎患者骨代谢生化标志物的变化及意义

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1、授予单位代码10089学号或申请号16128中国图书分类号R593.9HebeiMedicalUniversity硕士学位论文学术学位膝骨关节炎患者骨代谢生化标志物的变化及意义研究生：李会芳导师：王俊祥副教授专业：内科学二级学院：河北省第三医院研究起止期：2016年10月---2017年10月2018年3月目录中文摘要···························································································

2、···············1英文摘要··········································································································3英文缩写··········································································································6研究论文膝骨关节炎患者骨代

3、谢生化标志物的变化及意义前言··········································································································7材料与方法····························································································8结果······························

4、············································································11附图··········································································································13附表·····························································

5、·············································15讨论··········································································································18结论····························································································

6、··············21参考文献····························································································22综述骨关节炎发病机制及炎性细胞因子的研究进展····························27致谢···················································································

7、·······················36个人简历··········································································································37膝骨关节炎患者骨代谢生化标志物的变化及意义摘要目的：骨关节炎（OA）为临床常见的致残性疾病，特征性表现为滑膜关节软骨进行性退变及软骨下骨的重塑，炎症在其发病机制中发挥着重要作用。本研究通过检测膝骨性关节炎（KOA）患者骨代谢参数

8、BGP、CTX-1以及炎症因子IL-1的水平，以及分析这些指标与ESR、CRP、ALP等临床指标的相关关系，来了解OA患者骨代谢的情况，为进一步揭示骨关节炎发病机制提供新的参考依据，为骨关节炎的治疗提供新的思路。方法：选取我院（冀中能源邢矿集团总医院）住院的膝骨关节炎（KOA）患者56例，其中合并有滑膜炎者（SG）29例，无滑膜炎者（NSG）27例，并选取年龄和性别相匹配无膝骨关节炎症状的34例健康体检者为对照组。用双抗体夹心酶联免疫法（ABC-ELISA）测定KOA组与对照组血清