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1、2018-03-2712:00:30中国现代医生2018年3期沈文霞［摘要］目的探讨母亲妊娠期糖尿病(GDM)对子代胰岛素抵抗的影响，为改善子代生长发育提供依据。方法依据产妇是否合并妊娠期糖尿病把60例新生儿分为GDM组及对照组，每组各30例；检测新生儿脐血血糖(BG)、脐血糖化红蛋白(HbAlc)、脐血胰岛素(Ins)、出生体重，计算出每例新生儿胰岛素抵抗指数，分析妊娠期糖尿病与子代胰岛素抵抗的关系。结果GDM组母亲孕前体重及产前体重分别为(57.83±9.32)kg、(74.28±10.09)kg,新生儿岀生体重(3.81±0.25)kg,而對照组分
2、别为(53.61±8.45)kg、(68.77±8.76)kg、(3.13±0.55)kg,差异有统计学意义(P<0.05)。GDM组平均胰岛素抵抗指数为(1.49±0.39),对照组为(0.86±0.11),两组之间差异有统计学意义(PvO.05)。结论母亲妊娠期糖尿病增加子代胰岛素抵抗，值得关注。［关键词］妊娠期糖尿病；糖尿病母亲；新生儿；胰岛素抵抗［中图分类号］R714.2［文献标识码］A［文章编号］1673-9701(2018)03-0012-03Correlationbetweengestationaldiabetesmellitusandne
3、onatalinsulinresistaneeSHENWenxiaShaoxingMaternalandChildHealthHospitalinZhejiangProvince,Shaoxing312000,China［Abstract］ObjectiveToinvestigatetheinflueneeofmaternalgestationaldiabetesmellitus(GDM)oninsulinresistaneeinchildrenandtoprovidebasisforimprovingthegrowthanddevelopmentofc
4、hildren.MethodsAccordingtowhetherpregnantwomenhadgestationaldiabetesmellitusornot,60newbornsweredividedintoGMDgroupandcontrolgroup,with30casesineachgroup・Thelevelsofneonatalumbilicalbloodglucose(BG),umbilicalcordbloodglycosylatedhemoglobin(HbAlc),umbilicalbloodinsulin(Ins),birthw
5、eightweredetected.Andtheinsulinresistanceindexofeachnewbornwascalculated・Thecorrelationbetweenthegestationaldiabetesmellitusandneonatalinsulinresistaneewasanalyzed・ResultsThebodyweightofmothersbeforepregnancyanddeliveryandnewbornbirthweightintheGDMgroupwas(57.83±9.32)kg,(74.28±10
6、.09)kgand(3.81±0.25)kg,respectively,whilethoseinthecontrolgroupwas(53.61±8.45)kg,(68.77±8.76)kgand(3.13±0.55)kg,respectively.Thedifferencesintheabovedatabetweenthetwogroupswerestatisticallysignificant(P<0.05)・Themeaninsulinresistanceindexwas(1.49±0.39)inGDMgroupand(0.86±0.11)inco
7、ntrolgroup,withsignificantdiffereneebetweenthetwogroups(P<0.05).ConelusionGestationaldiabetesinmothersincreaseschildren'sinsulinresistanee,whichisworthyofattention.［Keywords］Gestationaldiabetes；Diabeticmother：Neonate；Insulinresistanee妊娠期糖尿病(gestationaldiabetesmellitus,GDM)是指妊娠期间首
8、次发现或发牛的不同严重程度的糖耐量异常，是妊娠期常见的并发症，其主耍临床表现为妊
