木瓜中抗炎镇痛有效部位的药学.研究

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1、壅丝堕型查兰曼兰兰垡丝苎一——Studiesonthepharmacyoftheeffectiveanti—inflammatoryandanalgesiccomponentfromchaenomelesspeciosaAbstractInordertoresearchtheoptimumtechnicsofproducingglycosidesofchaenomelesspeciosa(GCS)--theeffectiveanti—inflammatoryandanalgesiccomponentofchaeno

2、melesspeciosa，andtoestablishthequalitystandard，thepharmacodynamicsexperimentsofthreeextractsfromchaenomelesspeciosawerestudiedastheparameterofanti—inflammatoryandanalgesiceffect．Meanwhile，differentconditionsforextractingGCSwereanalyzedthroughtheorthogonaldesig

3、nexperimentswithanalysisofvariance，ThetechnicalconditionsandparametersofOCS’sillustrationandpurificationwithmacroporusadsorptiveresinwereinvestigated．ThequalitystandardsofGCSwereestabljshedTocomparetheanti—inflammatoryandanalgesiceffectsofthetotalextractsofcha

4、enomelesspeciosa(TECS)，GCSandnon—glycosidesofchenomelesspeciosafNGCS)，theearswellinginmicewithxylenewasused．Theanti—inflammatoryeffectsofthreeextractsfromchaenomelesspeciosawereobserved．hot-platetestwasusedtoassesspainthresholdinmice，andobservedtheanalgesiceff

5、ectsofthreeextractsfromchaenomelesspeciosa．GCS60，120，240mg．kg一1igsignificantlyinhibitedtheacuteimflammationinducedbyxylene，anddemonstratedthedose—relatedinhibitoryeffect，NGCS200，400rag．kg—hadrioinhibitoryeffect．WhenGCS120，240mg．kg一1administeredintragastrically

6、，thepainthresholdwasrisenremarkablyinmice，andtheanalgesiceffectwasdependentonthedosage．GCShadtheeffectofanti—inflammationandanalgesia．OCSistheeffectivecomponentofanti-inflammationandanalgesiafromchaenomelesspeciosa．4窒堂堕型查堂堕主兰垡堡苎一一Theoptimumpreparationprocessof

7、GCSwasinvestigatedbytheorthogonaldesignastheGCScontentindex，whichwasdeterminedbycolormetricmethodTheoptimumalcohol—extractingfactorswere8timesof80％alcohol，refiuxingandextractingforlh，for3times．ThetechnicalparametersofGCS’Spurificationwithmacroporousadsorptiver

8、esinwereinvestigated，andthequalitycontrolsystemwasestablished．ThistechniquewasagoodmethodtopurifyGCS．Thewatersolutionoftheoptimumalcohol—extractswasabsorbedforlhwithacolumnofmacrop