annexina7在喉鳞状细胞癌的表达

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1、ExpressionofAnnexinA7inlaryngealsquamouscellCarClnomaMasterdegreecandidate：XuSongSupervisor：ProfessorZhaiLijieMajor：OtorhinolaryngologyAbstractobjeetive：TostudythattheexpressionofAnnexinA7inlaryngealsquamouscellcarcinomaO。scc)isdifferentfromthatinadjacentnormallaryngealmucosaandmakeitcertaint

2、hatAnnexinA7mayplayanimportantroleintheoncogenesisandprogressionofLSCCasatumorsuppressorgeneandprovideakindofclinicaltargetforobservingandassessingthemalignantpotentialoflaryngealmucosa．Methods：TheexperimentdetectstheproteinexpressionofAnnexinA7bYimmunohistochemistry(MaxVisionTM)in31casesofLS

3、CCand32casesofadjacentnormallaryngealmucosatissuesandanalyzetherelationshipbetweentheexpressionofAnnexinA7andage，gender,anatomicaldistrict，pathologicalgradeorclinicalstageofthelaryngealcancerpatients．Results：1AnnexinA7proteinisabundantinthenormallaryngealmucosaandisfoundlocalizedinthecellmemb

4、ranebyimmunohistochemistry．Itismanifestedabrowngranularorlinenetworkdistribution．2neexpressionofAnnexinA7Canbedividedintofourgrades．Theyarenegative，weaklypositive，positiveandstronglypositiverespectively．Inthe31c觞esofLSCC，Thereare23casesnegative，5Oflk∞Sweaklypositive,1c觞epositiveand2CflSesstro

5、nglypositive．However,inthe32c嬲esofadjacentnormallaryngealmucosatissues，therealelcasenegative，2c嬲weaklypositive，9casespositiveand20c勰esstronglypositive．Thereismuchdifferencebetweenthetwogroupswhichistestedstatisticallysignificantbymeansofnonparametrictests．11heexpressionofAnnexinA7inLSCCismuch

6、lowerthanthatintheadjacentnormallaryngealmucosa．3A儿the31c嬲铭ofLSCCpatientsgallbedividedintotwogroupsaccordingtotheanatomicaldistrict,pathologicalgradeorclinicalstage．TheexpressionofAnnexinA7intwogroupsistestedbym锄sofnonparametrictestsanditisfoundthatthereisnosignificantdifference．Bythesamemean

7、s，therelationshipsamongtheexpressionof2AnnexinA7andtheage，gender，anatomicaldistrict，pathologicalgradeorclinicalstageofthelaryngealcancerpatientsaretestedtobenosignificantdifference．Conclusion：1TheA7proteiniswidespreadincells．Itislocalizedinth