他喹莫德和奥贝胆酸的合成研究

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1、浙江工业大学硕士学位论文insteadofsodiumhypochloritetosimplifytheexperimentaloperationandimprovethereactionyield.Inthenexttransformation,alsoknownasesterification,wefoundthatusingthecheap,easilypreservedK2CO3ascatalystcouldachieveahigheryieldthenCs2CO3.Throughreducingbenzylbromideto3equiva

2、lentwecouldpurifythefinalproductbyrecrystallizationwithoutcolumnchromatography.Thestructureof113ObeticholicAcidpreparedwasconfirmedbyMS,H-NMR,C-NMR,andDEPTandthepuritywas99.87%.Furthermore,twoisomersweresynthesizedtolaythefoundationofqualitycontroloffinalproductwhich113werecon

3、firmedbyMS,H-NMRandC-NMR.KEYWORDS:Tasquinimod,ObeticholicAcid,SynthesisV万方数据浙江工业大学硕士学位论文目录第一部分他喹莫德的合成研究........................................................11绪论..................................................................................................................

4、...11.1前言....................................................................................................................................11.1.1前列腺癌.................................................................................................................11.1.2前列腺癌药物研

5、究进展.........................................................................................21.1.2.1一线治疗药物..............................................................................................21.1.2.2治疗CRPC的药物............................................................

6、..........................21.1.3他喹莫德的介绍.....................................................................................................42他喹莫德的合成.................................................................................................52.1他喹莫德的合成路线综述................

7、................................................................................52.1.1他喹莫德的逆合成分析.........................................................................................52.1.2合成路线一.................................................................................

8、............................52.1.3合成路线二......................