中国hiv1感染者nkt细胞与疾病进展的相关性研究

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1、与CD4+T细胞无显著相关，CD4+NKT细胞与CD4-NKT细胞呈显著正相关。HIV／AIDS患者NKT细胞与CD4／CD8的比值显著正相关(r--0．32，P<0．05)。结论1、中国HIV／AIDS患者NKT细胞数量在疾病末期显著下降，与疾病进展相关。2、中国缓慢进展者维持高水平NKT细胞数量可能为其疾病缓慢进展的原因之一。关键词HIV，AIDS，NKT细胞，CCR54·英文论著摘要·StudyontheRelationshipbetweenTCRVa24+Vpll+NKTCellsandtheProgressionofHIV-1Inf

2、ectioninChinesePopulationPrefaceAIDS(acquiredimmunodeficiencysyndrome，AIDS)isaimmunedefectdiseasecausedbyHIV(humanimmunodeficiencyvirus，HIV)whichstillcallnotbecompletelycuredandmakebreakthroughinthevaccineresearchrightnow．Thebasicreasonliesinthelackofessentialunderstandingo

3、ftheHWbiologyandthemechanismofhumanorganismimmunereactionsandtheinteractionsbetweenthem，especiallythekeyregulatorintheimmunesystemisstillbarelyknown．Inimmunesystem，theNKTcell(naturekillerTcell)expressextremelyrestrictedTCRrepertoire，inhumanconsistingofaVa24chainpreferential

4、lypairedwithaV131chail=l’whichcouldactivateTcells，BcellsandNKcell，whichisthebridgebetweeninnateandadaptiveinlmunesystem，whichisoneofthekeyregularcells．Thus，thoughNKTcellsarepresentatverysmallnumbersinperipheralblood(between0．01and1％ofperipheralbloodmononuclearcells)，whichpl

5、ayimportantrolesinanti-virus，bacteria，fungus，parasite，tumor,andautoimmunediseases．SomereportssuggestthatduetotherelativelliglllevelofCCR5totheregularTcells，theperpetualactivatedstateofNKTcellsaremoreeffectivetargetsforR5-tropicHIV-1infectioninvivo．Co-administrationof0【·GalC

6、erwithsuboptimaldosesofDNAvaccinesgreatlyenhancedantigen—specificTcellandBcellresponses．Inall，NKTcellsmayplayaroleinthedevelopmentofHWinfectiondiseaseprogression．DuetothedifferenthereditybackgroundbetweenChineseandtheWesterner,thenumberofallkindsofcellandmoleculesnaybehighl

7、yvariable．InHIVinfectedChinese，therehasnostudyonthefrequencyofNKTcellsaccordingtodiseaseprogression．Inthepresentpaper,westudiedthefrequencyandCCR5levelofTCRV以4+Vp11扑ⅨTcellsandtheirrelationshiptothediseaseprogressionofHIV-1infectedpatientsinChina．5MaterialandMethods1．Studyob

8、jectsAtotalof53treatmentnaiveHIV-infectedpatientsfromHenanprovincesofChinawereenro