盐酸纳美芬注射液药代动力学

《盐酸纳美芬注射液药代动力学》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、重庆医科大学硕士研究生学位论文2l0healthyvolunteerswereintravenousinjectiongiven0．5mg，lmg，2mgNalmefenehydrochlorideforsingledoseinsuccession．TheplasmaandurinesamplewereCollectedaccordingtoprogrammedschedule．Theelectrosprayionizationpositiveselectedreactionmonitoringdetec

2、tionsforNalmefenehydrochlorideandallyln—oroxymorphone(theinternalstandard)intheplasmaandintheurinewereused．thepharmacokineticparametersanddependabilityofdeferencedosewerecalculatedby3P87SOftware．Andthesametimetheadversewererecorded．Result：1REVEXandNLXwasw

3、ellseparatedandtherewasnosignificantinterferentialpeak．themethodexhibitedagoodlinearityinO．04to625ng／mlofREVEXwiththelowestdetectionlimitof0．0008ng／mlinplasma．Thedeviationofrecoveryratiowasfoundintherangeof92．50％---．108．40％．andthestandardcurvewasY=0．0148x

4、+O．0055，r--0．9990，n211．BothRSDbetweendaysandwithindaywerealllowerthanl0％．Meanwhileintheurinesamples，agoodlinearityintherange0．2to625ng／mlandthelowestdetectionlimitof0．0003ng／m1．ThelimitofthedetectionforNalmefenehydrochloridewasO．0003ng／mlinurine．thestanda

5、rdcurvewascalculatedtobeY=O．0514x-0．0059，r=O．9999，n=9．Thedeviationofrecoveryratio90．OO％～108．40％．BothRSDbetweendaysandwithindaywerealllowerthan10％．TheseresultsshowedthemethodestablishedinthestudyisspecificfordeterminationofREVEXandcouldbeusedinresearchingd

6、rugpharmacokinetics．2ThepharmacokineticsofREVEXwerefittedinatwo—compartmentopenmodelfollowingintravenousadministrationsingledoseof0．5mg、lmg、2mgofNalmefenehydrochloride．theobtainedpharmacokineticparameterswereasfollowsrespectively：Cmaxwere(1．74+0．48)ug／L，(

7、4．16重庆医科大学硕士研究生学位论文7+1．08)ug／L，(7．88+2．89)ug／L；h／213were(12．83+3．98)h，(12．6+6．4)h，(10．58士3．74)h；Vwere(3．45士0．16)L／kg，(4．11+0．0716)(L／kg)、(4．25士0．56)L／kg：CLwere(O．81+0．11)L／hr／kg，(O．85土O．15)L／hr／kg，(O．87+0．11)L／hr／kg；AUCo．∞were(21．62+9．34)(ng／L)宰h，(24．8918

8、．52)ngm)木h，(35+11．2)ng／L)％；therewasasignificantcorrelationwasobservedbetweenthemeanpeakconcentrationandAUCo．∞．within48h，afteranintravenousadministrationsingledoseof0．5mg、lmg、2mgofNalmefenehydrochloride．theurineaccum