n-杂环卡宾催化的成环反应研究进展

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1、analogues[J].BioorgMedChemLett,2008,18(23):[J].OrgBiomolChem,2008,6(17):3177-3185.6156-6160.[20]ZOIDISG,KOLOCOURISN,NAESENSL,etal.Designand[14]STAMATIOUG,FOSCOLOSGB,FYTASG,etal.synthesisof1,2-annulatedadamantanepiperidineswithHeterocyclicrimantadineanalog

2、ueswithantiviralactivity[J].anti-influenzavirusactivity[J].BioorgMedChem,2009,BioorgMedChem,2003,11(24):5485-5492.17(4):1534-1541.[15]ZOIDISG,FYTASC,PAPANASTASIOUI,etal.[21]CADYSD,WANGJ,WUYB,etal.SpecificbindingofHeterocyclicrimantadineanalogueswithantivir

3、alactivity[J].adamantanedrugsanddirectionoftheirpolaraminesintheBioorgMedChem,2006,14(10):3341-3348.poreoftheinfluenzaM2transmembranedomaininlipid[16]TATARRIDISD,FYTASG,KOLOCOURISA,etal.bilayersanddodecylphosphocholinemicellesdeterminedbyInfluenceofanaddit

4、ional2-aminosubstituentoftheNMRspectroscopy[J].JAmChemSoc,2011,133(12):1-aminoethylpharmacophoregrouponthepotencyof4274-4284.rimantadineagainstinfluenzavirusA[J].BioorgMedChem[22]KOLOCOURISA,HANSENRK,BROADHURSTRW.Lett,2007,17(3):692-696.Interactionbetweena

5、namantadineanalogueandthe[17]ZARUBAEVVV,GOLODEL,ANFIMOVPM,etal.transmembraneportionoftheinfluenzaAM2proteininSynthesisandanti-viralactivityofazolo-adamantanesagainst1liposomesprobedbyHNMRspectroscopyoftheligand[J].JinfluenzaAvirus[J].BioorgMedChem,2010,18(

6、2):MedChem,2004,47(20):4975-4978.839-848.[23]SCHELLJR,CHOUJJ.StructureandmechanismoftheM2[18]LIW,LVL,QUJ,etal.DesignedandsynthesizedofProtonchannelofinfluenzaAvirus.[J].Nature,2008,amantadinederivstivesandtheiranti-avianinfluenzavirus451(7178):591-595.act

7、ivity[J].ChinJMedChem(中国药物化学杂志),2011,[24]STOUFFERAL,ACHARYAR,SALOMD,etal.Structural21(5):345-351.basisforthefunctionandinhibitionofaninfluenzavirus[19]ZOIDISG,TSOTINISA,KOLOCOURISN,etal.Designandprotonchannel[J].Nature,2008,451(7178):596-599.synthesisofbi

8、oactive1,2-annulatedadamantanederivatives收稿日期：2012-08-11N-杂环卡宾催化的成环反应研究进展倪佳婷，董晶，胡文君，杜文婷*(浙江医学高等专科学校药学系，杭州310053)摘要：目的介绍N-杂环卡宾催化的成环反应研究进展。方法综合国内外报道的文献，阐述N-杂环卡宾催化的成环反应。结果列出了N-杂环卡宾催化的分子内Stetter反应、亲核取代反应、环加成反应和串联反应等成环方法