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1、L.V.Chernysheva,R.M.Friendship,C.L.Gyles,andC.E.DeweyFieldTrialAssessmentoftheEfficacyofSpecificEgg-YolkAntibodyProductforControlofPostweaningE.coliDiarrhea*LarisaV.Chernysheva,DVM,MScaRobertM.Friendship,DVM,MSc,DABVPaCarltonL.Gyles,DVM,PhDbCatherineE.Dewey,DVM,MSc,PhDaaDepartmentof
2、PopulationMedicinebDepartmentofPathobiologyOntarioVeterinaryCollegeUniversityofGuelphGuelph,Ontario,CanadaN1G2W1nABSTRACTgardingthedevelopmentofresistanceandPostweaningdiarrheacausedbyEscherichiafrustrationfromlackofagoodclinicalre-coliisamajorcauseofmortalityandmorbiditysponsehasle
3、dtothesearchtofindalternativeinmanyswinenurseriesthroughoutNorthcontrolmeasures.AttemptstoreduceE.coliAmerica.Commercialproductscontainingpopulationsinthegastrointestinaltractin-chickenegg-yolkantibodiesspecificforthecon-cludetheprovisionofhighlevels(2,000ppmtrolofK88+E.colidiarrhea
4、havebeenusedinormore)ofzincoxideinfeed,3acidifiersinanattempttopreventdiseaselosses.Thepresentfeedandwater,andtheuseofnontraditionalstudyevaluatedtheuseofanegg-yolkantibodyproductssuchasherbsandessentialoils.Re-productincorporatedintonurseryfeedontwosearchersalsohaveexaminedtheuseof
5、prebi-farmswhereK88+E.colidiarrheawasidentifiedoticsandprobioticstodetermineiftheseprod-asaproblem.Therewerenodifferencesintheuctsmightbeusefulinalteringgutflorainprevalenceofdiarrheaormortalitybetweenweanedpigs.4treatmentandcontrolpigsateitherfarmunderAsignificantfactorintheprolife
6、rationofE.routinemanagementconditions.coliatthetimeofweaning,asidefromthedra-maticchangeindiet,isthesuddenlossofim-nINTRODUCTIONmunoglobulinsobtainedfromsow’smilk.E.colidiarrheainweanedpigsisanimpor-PathogenicE.colifrequentlychallengesthetantdiseaseproblemintheNorthAmericannewlywean
7、edpigbeforelocalgutimmunitypigindustry.1,2Treatmentwithantibioticshashassufficientlydeveloped.Providingpassivebeenthetraditionalapproach,butconcernre-immunityintheformofspecificim-munoglobulinsagainstK88+E.colihasbeen*ThisworkwassupportedinpartbygrantsfromOntarioPork,Guelph,Ontarioa
8、ndtheUniversitysugg
