黄连碱对内毒素发热大鼠解热、抗炎作用的PK-PD模型研究

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1、ChengduUniversityofTraditionalChineseMedicine（药学院）二0一八届硕士研究生学位论文黄连碱对内毒素发热大鼠解热、抗炎作用的PK-PD模型研究Pharmacokinetic-pharmacodynamicstudyonantipyreticeffectsandanti-inflammatoryofCoptisineonendotoxin-inducedpyrexiaofrats研究生姓名：王丽指导教师：王平副教授学科专业：药理学二0一八年五月学位论文黄连碱对内毒素发热大鼠解热、抗炎作用的PK-PD模型研究Pharmacokineti

2、c-pharmacodynamicstudyonantipyreticeffectsandanti-inflammatoryofCoptisineonendotoxin-inducedpyrexiaofrats王丽指导教师姓名：王平副教授申请学位级别：硕士专业名称：药理学论文提交时间：2018年4月论文答辩时间：2018年5月二0一八目录中文摘要....................................................................................................................

3、................IAbstract..................................................................................................................................III英文缩略词表.........................................................................................................................VI前言.

4、..........................................................................................................................................11黄连碱的药理活性研究进展................................................................................................12炎症因子与体温的相互调节作用..........................

5、.............................................................23PK-PD模型与炎症反应........................................................................................................44研究思路.........................................................................................................

6、.......................5第一部分黄连碱的方法学考察.............................................................................................81.1实验材料........................................................................................................................81.1.1实验耗材及仪器...................

7、...................................................................................81.1.2实验药品与试剂......................................................................................................91.1.3实验动物及场所.................................................