冠状动脉病变程度与左室舒张功能的相关性研究

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1、授予单位代码10089学号或申请号13004V妗(£搿大空HebeiMedicalUniversity硕士学位论文在职科学学位冠状动脉病变程度与左室舒张功能的相关性研究学位申请人：李春彦导师：齐晓勇教授专业：内科学二级学院：河北省人民医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科

2、大学所有。否则，承担相应法律责任。/'樣人>二级学院领导毒筆梦\rtm#/河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：导师签章:yny年J"月》1曰目录中文摘要·············································································1英文摘要·································

3、············································3研究论文冠状动脉病变程度与左室舒张功能的相关性研究前言·············································································6材料与方法····································································7结果··································································

4、···········9附图·············································································10附表·············································································11讨论·············································································14结论···································

5、··········································16参考文献·······································································16综述左心舒张功能不全及其检测方法······································21致谢···················································································28个人简历························

6、·····················································29中文摘要冠状动脉病变程度与左室舒张功能的相关性研究摘要背景：我们在临床工作中发现许多年轻冠心病患者超声心动图E/Ea比值较大，提示舒张功能不全，但患者无明显高血压、心肌肥厚等引起左室舒张功能不全的因素，甚至糖尿病时间并不长，而冠脉造影提示有明显的冠脉狭窄性病变，考虑其心功能不全与冠脉病变有一定关系，故收集符合入选标准的均行冠脉造影检查及超声心动图检查的患者资料139例，进行冠心病冠脉病变程度与左室舒张功能的相关性分析，观察其关系，从而对评估患者预后及指导进一步治疗提供帮

7、助。目的：本研究通过设定患者冠脉病变程度、血糖、总胆固醇、甘油三脂、高密度胆固醇、低密度胆固醇、同型半胱氨酸为自变量，患者超声心动图E/A比值、E’值、EE’比值这些心脏舒张功能相关的指标为应变量，多元线性回归分析观察冠状动脉病变程度等与左室舒张功能之间的关系，探讨其临床意义。因糖尿病、年龄、同型半胱氨酸、血脂等因素均对舒张功能存在影响，同时观察了这些指标与左室舒张功能及冠脉病变的关系，对主要研究目的有一定排除意义。方法：回顾2014年4月～2015年2月在我院（河北北方学院附属第二医院）