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1、PFCgapjunctiondysfunctioninducesdepressionJ-DSunetalNeuropsychopharmacology(2012)37,1305-1320®2012AmericanCollegeofNeuropsychopharmacology.Allnghtsreserved0893-133X/I2www.neuropsychopharmacology.orgGapJunctionDysfunctioninthePrefrontalCortexInducesDepressive-L
2、ikeBehaviorsinRatsJian-DongSun1,YanLiu_,Yu-HeYuan1,JingLi1andNai-HongChen*，1StateKeyLaboratoryofBioactiveSubstancesandFunctionsofNaturalMeaicmes,DeportmentofPharmacology,InstituteofMateriaMedico,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beiji
3、ng,ChinaGrowingevidencehasimplicatedglialanomaliesinthepathophysiologyofmajordepressiondisorder(MDD).Gapjunctionalcommunicationisamaindeterminantofastrocyticfunction.However,itisunclearwhethergapjunctiondysfunctionisinvolvedinMDDdevelopmentThisstudyinvestigate
4、schangesinthefunctionofastrocytegapjunctionoccurringintheratprefrontalcortex(PFC)afterchronicunpredictablestress(CUS),arodentmodelofdepression.AnimalsexposedtoCUSandshowingbehavioraldencitsinsucrosepreferencetest(SPT)andnoveltysuppressedfeedingtest(NSFT)exhibi
5、tedsignificantdecreasesindiffusionofgapjunctionchannel-permeabledyeandexpressionofconnexin43(Cx43),amajorcomponentofastrocytegapjunction,andabnormalgapjunctionalultrastructureinthePFCFurthermore,weanalyzedtheeffectsoftypicalantidepressantsfluoxetineandduloxeti
6、neandglucocorticoidreceptor(GR)antagonistmifepristoneonCUS-inducedgapjunclionaldysfunctionanddepressive-likebehaviors.ThecellularandbehavioralalterationsinducedbyCUSwerereversedand/orblockedbytreatmentwithtypicalantidepressantsormifepristone,indicatingthatthem
7、echanismoftheirantidepressantactionmayinvolvetheameliorationofgapjunctiondysfunctionandthecellularchangesmayberelatedtoGRactivation.WetheninvestigatedtheeffectsofpharmacologicalgapjunctionblockadeinthePFCondepressive-likebehaviors.Theresultsdemonstratethatcarb
8、enoxolone(CBX)infusionsinducedanhedoniainSPT,andanxietyinNSFT,andCx43mimeticpeptiaesGap27andGap26alsoinducedanhedonia,acoresymptomofdepression.Together,thisstudysupportsthehypothes
